Onodera H, Kogure K, Ono Y, Igarashi K, Kiyota Y, Nagaoka A
Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
Neurosci Lett. 1989 Mar 13;98(1):101-4. doi: 10.1016/0304-3940(89)90381-9.
The amounts of mRNAs for proto-oncogene c-fos and structural protein beta-actin were measured in the rat cerebral cortex after transient forebrain ischemia. A transient and specific induction of c-fos mRNA was noticed in the cerebral cortex 30-90 min after ischemia followed by decline to control value. In contrast, the level of mRNA for beta-actin was not altered throughout the recirculation period examined. These results suggest specific role of c-fos gene after brain damage.
短暂性前脑缺血后，测定大鼠大脑皮质中原癌基因c-fos和结构蛋白β-肌动蛋白的mRNA含量。缺血后30 - 90分钟，大脑皮质中c-fos mRNA出现短暂而特异性的诱导，随后下降至对照值。相比之下，在所检测的再灌注期间，β-肌动蛋白的mRNA水平没有改变。这些结果提示c-fos基因在脑损伤后具有特定作用。
