Mariano Eric Domingos, Batista Chary Marquez, Barbosa Breno José Alencar Pires, Marie Suely Kazue Nagahashi, Teixeira Manoel Jacobsen, Morgalla Matthias, Tatagiba Marcos, Li Jun, Lepski Guilherme
Departamento de Neurologia, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil.
Department of Neurosurgery, Eberhard-Karls University, Tuebingen, Germany.
Arq Neuropsiquiatr. 2014 Jun;72(6):451-6. doi: 10.1590/0004-282x20140051.
Spinal cord injury (SCI) and amyotrophic laterals sclerosis (ALS) are devastating neurological conditions that affect individuals worldwide, significantly reducing quality of life, both for patients and their relatives.
The present review aims to summarize the multiple restorative approaches being developed for spinal cord repair, the use of different stem cell types and the current knowledge regarding stem cell therapy.
Review of the literature from the past 10 years of human studies using stem cell transplantation as the main therapy, with or without adjuvant therapies.
The current review offers an overview of the state of the art regarding spinal cord restoration, and serves as a starting point for future studies.
脊髓损伤（SCI）和肌萎缩侧索硬化症（ALS）是严重的神经系统疾病，影响着全球各地的人们，显著降低了患者及其亲属的生活质量。
本综述旨在总结目前正在开发的多种脊髓修复恢复方法、不同干细胞类型的使用以及有关干细胞治疗的现有知识。
回顾过去10年以干细胞移植作为主要治疗方法（无论有无辅助治疗）的人体研究文献。
本综述概述了脊髓修复的当前技术水平，并为未来研究提供了一个起点。
