Clinic of Medicine, Faculty of Veterinary Science, University of Thessaly, Karditsa, Greece.
Companion Animal Clinic, School of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Vet Clin Pathol. 2020 Sep;49(3):389-393. doi: 10.1111/vcp.12896. Epub 2020 Oct 16.
An 8-month-old female domestic shorthair cat was presented to the Animal Medical Center with anorexia, lethargy, and mild gastrointestinal signs. A CBC revealed a profound neutropenia, and serologic testing with an in-house test kit (SNAP FIV/FeLV Combo, IDEXX) was positive for feline leukemia virus (FeLV) antigen. Serial hematologic examinations during hospitalization showed a persistent neutropenia with occasionally severe anemia and thrombocytopenia. Prednisolone administration afforded complete hematologic remission within 3 days. Four weeks after the premature discontinuation of prednisolone, the patient relapsed; however, complete and prolonged hematologic remission was achieved after prednisolone was re-induced. Bone marrow aspiration cytology was consistent with immune-mediated destruction of the mature myeloid cells. steroid-responsive (likely immune-mediated) cytopenias rarely occur in cats with progressive FeLV infection. Although only a few cases of FeLV-positive, severely neutropenic cats that responded to immunosuppressive therapy have been reported, this case highlights that a grave prognosis should not always be given to these FeLV-positive cats.
一只 8 月龄雌性家短毛猫因厌食、嗜睡和轻度胃肠道症状到动物医疗中心就诊。全血细胞计数显示严重中性粒细胞减少，使用内部试剂盒（SNAP FIV/FeLV Combo，IDEXX）进行血清学检测呈猫白血病病毒 (FeLV) 抗原阳性。住院期间的系列血液检查显示持续中性粒细胞减少，偶尔出现严重贫血和血小板减少。泼尼松龙治疗在 3 天内完全缓解血液学异常。泼尼松龙过早停药 4 周后，患者复发；然而，重新诱导泼尼松龙治疗后，血液学异常完全且持久缓解。骨髓抽吸细胞学检查与成熟髓细胞的免疫介导破坏一致。在进行性 FeLV 感染的猫中，类固醇反应性（可能为免疫介导）血细胞减少症很少见。尽管仅报道了少数几例对免疫抑制治疗有反应的 FeLV 阳性、严重中性粒细胞减少的猫，但该病例强调，不应总是对这些 FeLV 阳性猫做出预后不良的判断。
