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Proliferation of B cells from chronic lymphocytic leukemia is selectively promoted by B cell growth factor.

作者信息

Alvarez-Mon M, de la Hera A, Gaspar M L, Orfao A, Casas J, Jordá J, Durantez A

机构信息

Departamento de Medicina, Universidad de Alcalá de Henares, España.

出版信息

Acta Haematol. 1989;81(2):91-7. doi: 10.1159/000205533.

DOI:10.1159/000205533
PMID:2496557
Abstract

B cell activation was studied in B cells from B cell chronic lymphocytic leukemia (B-CLL) patients. After in vitro stimulation, these B cells showed extensive proliferation in the presence of high-molecular-weight B cell growth factor (BCGF). In contrast, this effect was not observed upon addition of recombinant interleukin-2 (IL-2). In agreement, upon stimulation, B cells expressed Bac-1 antigen but failed to acquire the IL-2 receptor. These results demonstrate that the utilization of the BCGF pathway can be segregated from that of IL-2 in B cells from B-CLL patients.

摘要

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Proliferation of B cells from chronic lymphocytic leukemia is selectively promoted by B cell growth factor.
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J Clin Pathol. 1995 May;48(5):482-7. doi: 10.1136/jcp.48.5.482.
3
Functional impairment of natural killer cells in active ulcerative colitis: reversion of the defective natural killer activity by interleukin 2.
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