Beijing Engineering Research Center for BioNanotechnology and CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, 11 Beiyitiao, ZhongGuanCun, Beijing, 100190, China.
Nanoscale. 2014 Aug 7;6(15):8543-50. doi: 10.1039/c4nr01937g.
Here we report the antithrombotic functions of pyrimidinethiol-capped gold nanoparticles (Au_DAPT NPs). They can prolong coagulation parameters when injected intravenously in normal mice. Applied in two typical thrombosis models, mice tail thrombosis and pulmonary thromboembolism, gold NPs can inhibit both thrombosis and improve the survival rates of mice tremendously, without increasing the bleeding risk. The anticoagulant mechanisms include inhibiting the platelet aggregation as well as interfering with thrombin and fibrin generation.
在这里，我们报告了嘧啶硫醇封端的金纳米粒子（Au_DAPT NPs）的抗血栓功能。当它们在正常小鼠中静脉注射时，可以延长凝血参数。在两种典型的血栓形成模型中，即小鼠尾巴血栓形成和肺血栓栓塞中，金纳米粒子可以抑制血栓形成，并极大地提高小鼠的存活率，而不会增加出血风险。抗凝机制包括抑制血小板聚集以及干扰凝血酶和纤维蛋白生成。
