Woodward Christopher J, Deyo Zachariah M, Donahue Katrina E, Deal Allison M, Hawes Emily M
UNC Eshelman School of Pharmacy, Chapel Hill, North Carolina, USA.
University of North Carolina Hospitals and Clinics, Chapel Hill, North Carolina, USA.
BMJ Case Rep. 2014 Jun 25;2014:bcr2013009608. doi: 10.1136/bcr-2013-009608.
We present a case of clinically relevant and probable interaction between warfarin and scuppernongs in a 73-year-old woman where ingestion of scuppernongs, a variety of quercetin-containing muscadine grapes, over a period of 2 months was associated with elevations in the International Normalised Ratio to supratherapeutic levels. While muscadine grapes and specifically scuppernongs are found primarily in Southeastern USA, the flavonoid in questionand quercetin is found worldwide as a dietary supplement.
我们报告了一例73岁女性华法林与斯卡珀农葡萄之间存在临床相关且可能的相互作用的病例。在2个月的时间里，该女性摄入了斯卡珀农葡萄（一种富含槲皮素的圆叶葡萄），国际标准化比值升高至治疗水平以上。虽然圆叶葡萄，特别是斯卡珀农葡萄主要生长在美国东南部，但这种有问题的黄酮类化合物——槲皮素作为一种膳食补充剂在世界各地都有发现。
