Division of Applied Health Sciences, School of Medicine & Dentistry, University of Aberdeen, Aberdeen, UK.
Heart. 2014 Oct;100(20):1613-9. doi: 10.1136/heartjnl-2014-305816.
To study the utility of body fat percentage in predicting health outcomes when other obesity indices are considered.
We conducted a prospective cohort study to evaluate the independent utility of body fat percentage and other obesity indices in predicting mortality and cardiovascular disease (CVD).
We prospectively followed 15 062 European Prospective Investigation into Cancer (EPIC)-Norfolk participants who attended a health examination during 1997–2000 for all-cause mortality and incidence of CVD up to end of December 2011 and end of March 2009, respectively. During the follow-up, 2420 died and 4665 had incident CVD. After exclusion of prior stroke, myocardial infarction and cancer and adjusting for potential confounders, body mass index (BMI) and waist-to- hip ratio (WHR), the HR of mortality for men were 0.86 (0.68 to 1.09), 0.81 (0.61 to 1.07) and 0.76 (0.55 to 1.05) and for women were 0.91 (0.70 to 1.17), 0.75 (0.55 to 1.02) and 0.87 (0.61 to 1.23) for second, third and fourth quartile compared with the first (bottom) quartile of body fat percentage. The respective HRs for incident CVD were 0.99 (0.83 to 1.19), 0.85 (0.69 to 1.04) and 0.81 (0.64 to 1.03) for men and 0.98 (0.82 to 1.17), 0.89 (0.73 to 1.10) and 1.02 (0.81 to 1.29) for women. In contrast, higher BMI and WHR were associated with an increased risk of both outcomes and WHR appeared to have the best predictive value among three indices.
Once BMI and WHR are taken into account, fat percentage does not add to prediction of mortality or CVD in middle-aged and older-aged adults.
研究在考虑其他肥胖指数的情况下，体脂百分比在预测健康结果方面的作用。
我们进行了一项前瞻性队列研究，以评估体脂百分比和其他肥胖指数在预测死亡率和心血管疾病（CVD）方面的独立作用。
我们前瞻性地随访了 15062 名参加 1997-2000 年欧洲癌症前瞻性调查（EPIC）-诺福克健康检查的参与者，随访时间分别为所有原因死亡率和 CVD 发生率至 2011 年 12 月底和 2009 年 3 月底。在随访期间，2420 人死亡，4665 人发生 CVD。排除既往卒中、心肌梗死和癌症后，并调整了潜在混杂因素，男性的死亡率 HR 分别为 0.86（0.68 至 1.09）、0.81（0.61 至 1.07）和 0.76（0.55 至 1.05），女性分别为 0.91（0.70 至 1.17）、0.75（0.55 至 1.02）和 0.87（0.61 至 1.23），与体脂百分比的第二、第三和第四四分位相比。相应的 CVD 发生率 HR 分别为 0.99（0.83 至 1.19）、0.85（0.69 至 1.04）和 0.81（0.64 至 1.03），男性为 0.98（0.82 至 1.17）、0.89（0.73 至 1.10）和 1.02（0.81 至 1.29），女性为 0.98（0.82 至 1.17）、0.89（0.73 至 1.10）和 1.02（0.81 至 1.29）。相比之下，较高的 BMI 和 WHR 与这两种结局的风险增加相关，而 WHR 在这三个指标中似乎具有最佳的预测价值。
在考虑 BMI 和 WHR 后，体脂百分比不能增加对中年和老年成年人死亡率或 CVD 的预测。
