Lim In-Soo
Department of Physical Education, Changwon National University, Changwon, Republic of Korea.
Phys Act Nutr. 2020 Dec;24(4):28-33. doi: 10.20463/pan.2020.0025. Epub 2020 Dec 31.
This study aimed to investigate the effects of branched-chain amino acid (BCAA) supplement on delayed onset muscle soreness (DOMS) by analyzing the maximum muscle strength and indicators of muscle damage.
Twelve men with majors in physical education were assigned to the BCAA group and placebo group in a double-blinded design, and repeated measurements were conducted. DOMS was induced with an isokinetic exercise. Following BCAA administration, the changes in the knee extension peak torque, flexion peak torque, aspartate aminotransferase (AST), creatine kinase (CK), and lactate dehydrogenase (LDH) concentrations were analyzed. The maximum knee muscle strength was measured at the baseline (pre-D0) following BCAA administration for 5 days before exercise (-D5, -4D, -3D, -2D, -1D). In contrast, the post-treatment measurements (D3) were recorded after BCAA administration for 3 days (post-D0, D1, D2). Blood samples were obtained before (pre-D0), immediately after (post-D0), 24 h (D1), 48 h (D2), and 72 h (D3) after the exercise to analyze the indicators of muscle strength. BCAA was administered twice daily for 8 days (5 days and 3 days before inducing DOMS and during the experimental period, respectively).
There was no difference in the flexion peak torque between the groups. However, the BCAA group showed a significantly higher extension peak torque at D3 (second isokinetic exercise), compared to the placebo group (p<.05). There was no difference in AST changes between the groups. Nonetheless, the CK and LDH were significantly reduced in the BCAA group, compared to the placebo group. There was no correlation between the extension peak torque and flexion peak torque. However, the CK and LDH increased proportionately in DOMS. Moreover, their concentrations significantly increased with a decreasing peak torque (p<.01).
An exercise-induced DOMS results in a decrease in the peak torque and a proportional increase in the CK and LDH concentrations. Moreover, the administration of BCAA inhibits the reduction of the extension peak torque and elevation of CK and LDH concentrations. Therefore, BCAA might be administered as a supplement to maintain the muscle strength and prevent muscle damage during vigorous exercises that may induce DOMS in sports settings.
本研究旨在通过分析最大肌肉力量和肌肉损伤指标，探讨补充支链氨基酸（BCAA）对延迟性肌肉酸痛（DOMS）的影响。
采用双盲设计将12名体育专业男性分为BCAA组和安慰剂组，并进行重复测量。通过等速运动诱导DOMS。在给予BCAA后，分析膝关节伸展峰值扭矩、屈曲峰值扭矩、天冬氨酸转氨酶（AST）、肌酸激酶（CK）和乳酸脱氢酶（LDH）浓度的变化。在运动前5天（-D5、-4D、-3D、-2D、-1D）给予BCAA后，于基线（运动前D0）测量膝关节最大肌肉力量。相反，在给予BCAA 3天（运动后D0、D1、D2）后记录治疗后测量值（D3）。在运动前（运动前D0）、运动后即刻（运动后D0）、运动后24小时（D1）、48小时（D2）和72小时（D3）采集血样，分析肌肉力量指标。BCAA每天给药两次，共8天（分别在诱导DOMS前5天和3天以及实验期间）。
两组之间的屈曲峰值扭矩没有差异。然而，与安慰剂组相比，BCAA组在D3（第二次等速运动）时的伸展峰值扭矩显著更高（p<0.05）。两组之间AST变化没有差异。尽管如此，与安慰剂组相比，BCAA组的CK和LDH显著降低。伸展峰值扭矩和屈曲峰值扭矩之间没有相关性。然而，在DOMS中CK和LDH成比例增加。此外，它们的浓度随着峰值扭矩的降低而显著增加（p<0.01）。
运动诱导的DOMS导致峰值扭矩降低，CK和LDH浓度成比例增加。此外，给予BCAA可抑制伸展峰值扭矩的降低以及CK和LDH浓度的升高。因此，在可能在运动环境中诱导DOMS的剧烈运动期间，BCAA可作为一种补充剂来维持肌肉力量并预防肌肉损伤。
