Zhu Xiangyang, Gu Jinlou, Wang Yao, Li Bing, Li Yongsheng, Zhao Wenru, Shi Jianlin
Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
Chem Commun (Camb). 2014 Aug 14;50(63):8779-82. doi: 10.1039/c4cc02570a. Epub 2014 Jun 26.
Zr-based MOF nanoparticles were applied as efficient carriers for alendronate delivery, and an unprecedented drug loading capacity was achieved thanks to the inherent drug anchorages of Zr-O clusters therein. The encapsulated drug featured with a pH-dependent release profile, and inhibited the growth of cancer cells more efficiently than the free drug.
锆基金属有机框架纳米颗粒被用作阿仑膦酸盐递送的有效载体，由于其中Zr-O簇的固有药物锚定作用，实现了前所未有的载药量。封装的药物具有pH依赖性释放曲线，并且比游离药物更有效地抑制癌细胞的生长。
