牙齿健康与急性心肌梗死之间的关联。
Association between dental health and acute myocardial infarction.
作者信息
Mattila K J, Nieminen M S, Valtonen V V, Rasi V P, Kesäniemi Y A, Syrjälä S L, Jungell P S, Isoluoma M, Hietaniemi K, Jokinen M J
机构信息
First Department of Medicine, Helsinki University Central Hospital, Finland.
出版信息
BMJ. 1989 Mar 25;298(6676):779-81. doi: 10.1136/bmj.298.6676.779.
Known risk factors for coronary heart disease do not explain all of the clinical and epidemiological features of the disease. To examine the role of chronic bacterial infections as risk factors for the disease the association between poor dental health and acute myocardial infarction was investigated in two separate case-control studies of a total of 100 patients with acute myocardial infarction and 102 controls selected from the community at random. Dental health was graded by using two indexes, one of which was assessed blind. Based on these indexes dental health was significantly worse in patients with acute myocardial infarction than in controls. The association remained valid after adjustment for age, social class, smoking, serum lipid concentrations, and the presence of diabetes. Further prospective studies are required in different populations to confirm the association and to elucidate its nature.
已知的冠心病危险因素并不能解释该疾病的所有临床和流行病学特征。为了研究慢性细菌感染作为该疾病危险因素的作用，在两项独立的病例对照研究中，对总共100例急性心肌梗死患者和从社区中随机选取的102名对照者进行了不良口腔健康与急性心肌梗死之间关联的调查。使用两个指标对口腔健康进行分级，其中一个指标是在不知情的情况下进行评估的。基于这些指标，急性心肌梗死患者的口腔健康明显比对照者差。在对年龄、社会阶层、吸烟、血脂浓度和糖尿病的存在进行调整后，这种关联仍然成立。需要在不同人群中进行进一步的前瞻性研究，以证实这种关联并阐明其性质。
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