Rasi V, Ikkala E, Valtonen V
Thromb Res. 1982 May 15;26(4):267-74. doi: 10.1016/0049-3848(82)90291-2.
The plasma concentration of beta-thromboglobulin was serially measured in nine patients with septicemia, ten patients with pneumonia and five thrombo- and granulocytopenic patients with acute leukemia. Six patients with septicemia out of the eight studied on days 1-3 and all eight patients studied 7-14 days after onset had an abnormal high beta-thromboglobulin level. One patient with pneumonia out of six studied on days 1-3 and six out of nine studied on 7-14 days after onset had an abnormal high value. A rising trend in plasma beta-thromboglobulin with the highest mean levels at one to two weeks after onset was common to both groups. Positive ethanol gelation, increased level of fibrin/fibrinogen degradation products, decreased antithrombin III, increased FVIII complex and disproportionate ratio of FVIII:C to FVIIIR:Ag were common in both groups in the early stages of the disease. All the five patients with leukemia had a lower than normal beta-thromboglobulin level throughout the study but showed in the coagulation parameters changes similar to those observed in the other groups. Judging from the commonness of abnormal beta-thromboglobulin values in the two first patient groups, low grade platelet activation is a normal response in severe infection.
对9例败血症患者、10例肺炎患者和5例急性白血病伴血栓形成和粒细胞减少的患者连续测定β-血小板球蛋白的血浆浓度。在发病第1 - 3天研究的8例败血症患者中，有6例患者β-血小板球蛋白水平异常升高，在发病7 - 14天后研究的所有8例患者均如此。在发病第1 - 3天研究的6例肺炎患者中，有1例患者β-血小板球蛋白水平异常升高，在发病7 - 14天后研究的9例患者中有6例患者β-血小板球蛋白水平异常升高。两组患者血浆β-血小板球蛋白水平在发病后1至2周均呈上升趋势，且平均水平最高。两组患者在疾病早期均常见乙醇凝胶试验阳性、纤维蛋白/纤维蛋白原降解产物水平升高、抗凝血酶III降低、FVIII复合物增加以及FVIII:C与FVIIIR:Ag比例失调。在整个研究过程中，所有5例白血病患者的β-血小板球蛋白水平均低于正常，但在凝血参数方面出现了与其他组相似的变化。从最初两组患者β-血小板球蛋白值异常的普遍性来看，轻度血小板活化是严重感染时的一种正常反应。
