Velasco John Mark S, Alera Ma Theresa P, Ypil-Cardenas Charity Ann, Dimaano Efren M, Jarman Richard G, Chinnawirotpisan Piyawan, Thaisomboonsuk Butsaya, Yoon In-Kyu, Cummings Derek A, Mammen Mammen P
Southeast Asian J Trop Med Public Health. 2014 Mar;45(2):337-45.
We evaluated the differences in demographic, clinical, and laboratory findings between adult and pediatric patients hospitalized with dengue fever. Ninety patients with dengue infection admitted at San Lazaro Hospital (SLH), Manila from September 2005 to January 2006 were included in the study. The cases were laboratory-confirmed to have dengue infection. The majority of dengue cases (92%) had secondary dengue infection (median age = 18, age range: 2-37) while the remainder (8%) had a primary dengue infection (median age = 12, age range: 7-22). Nearly all the patients (99%) had dengue hemorrhagic fever (DHF). Sixty-five of the cases (72%) had serotype data: 2 (3%) were dengue virus serotype 1 (DENV-1) (median age = 17), 12 (18%) had DENV-2 (median age = 17.5), 38 (59%) had DENV-3 (median age = 16) and 13 (20%) had DENV-4 (median age = 18). The initial signs, symptoms and laboratory results except hematocrit (p = 0.02) and hemoglobin (p = 0.02) did not differ significantly between adults and children. During the study period, half the cases were adults (218 years; n = 45) and half were children (<18 years; n = 45). The ages of cases ranged from 2 to 37 years (median = 17 years) and the peak incidence was 15-19 years. Dengue is often considered as a pediatric disease. Additional studies are needed to determine if an age shift is occurring and where.
我们评估了登革热住院成人患者与儿童患者在人口统计学、临床和实验室检查结果方面的差异。2005年9月至2006年1月在马尼拉圣拉萨罗医院（SLH）收治的90例登革热感染患者纳入本研究。这些病例经实验室确诊为登革热感染。大多数登革热病例（92%）为继发性登革热感染（中位年龄 = 18岁，年龄范围：2 - 37岁），其余（8%）为原发性登革热感染（中位年龄 = 12岁，年龄范围：7 - 22岁）。几乎所有患者（99%）患有登革出血热（DHF）。65例（72%）病例有血清型数据：2例（3%）为登革病毒血清型1（DENV - 1）（中位年龄 = 17岁），12例（18%）为DENV - 2（中位年龄 = 17.5岁），38例（59%）为DENV - 3（中位年龄 = 16岁），13例（20%）为DENV - 4（中位年龄 = 18岁）。除血细胞比容（p = 0.02）和血红蛋白（p = 0.02）外，成人与儿童在初始体征、症状和实验室检查结果方面无显著差异。在研究期间，一半病例为成人（≥18岁；n = 45），一半为儿童（<18岁；n = 45）。病例年龄范围为2至37岁（中位年龄 = 17岁），发病高峰为15 - 19岁。登革热常被视为一种儿科疾病。需要进一步研究以确定是否正在发生年龄变化以及变化发生在哪里。
