用于模拟肿瘤血管生成的3D体外微环境的水凝胶。
Hydrogels to model 3D in vitro microenvironment of tumor vascularization.
作者信息
Song Hyun-Ho Greco, Park Kyung Min, Gerecht Sharon
机构信息
Department of Chemical and Biomolecular Engineering, Johns Hopkins Physical Sciences - Oncology Center and Institute for NanoBioTechnology, 3400 North Charles street, Baltimore, MD 21218, USA.
Department of Chemical and Biomolecular Engineering, Johns Hopkins Physical Sciences - Oncology Center and Institute for NanoBioTechnology, 3400 North Charles street, Baltimore, MD 21218, USA.
出版信息
Adv Drug Deliv Rev. 2014 Dec 15;79-80:19-29. doi: 10.1016/j.addr.2014.06.002. Epub 2014 Jun 23.
A growing number of failing clinical trials for cancer therapy are substantiating the need to upgrade the current practice in culturing tumor cells and modeling tumor angiogenesis in vitro. Many attempts have been made to engineer vasculature in vitro by utilizing hydrogels, but the application of these tools in simulating in vivo tumor angiogenesis is still very new. In this review, we explore current use of hydrogels and their design parameters to engineer vasculogenesis and angiogenesis and to evaluate the angiogenic capability of cancerous cells and tissues. By coupling these hydrogels with other technologies such as lithography and three-dimensional printing, one can create an advanced microvessel model as microfluidic channels to more accurately capture the native angiogenesis process.
越来越多癌症治疗临床试验的失败证实了升级当前肿瘤细胞培养和体外肿瘤血管生成建模实践的必要性。人们已多次尝试利用水凝胶在体外构建血管，但这些工具在模拟体内肿瘤血管生成方面的应用仍非常新颖。在本综述中，我们探讨了水凝胶的当前用途及其设计参数，以构建血管发生和血管生成，并评估癌细胞和组织的血管生成能力。通过将这些水凝胶与光刻和三维打印等其他技术相结合，可以创建一个先进的微血管模型作为微流体通道，以更准确地捕捉天然血管生成过程。
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