Alizadeh Naader, Shamaeli Ehsan, Fazili Masooma
Department of Chemistry, Faculty of Sciences, Tarbiat Modares University, P.O. Box 14115-175, Tehran, Iran.
Pharm Res. 2017 Jan;34(1):113-120. doi: 10.1007/s11095-016-2044-8. Epub 2016 Oct 19.
The potential of electrochemical/temperature dual stimuli-responsive conducting polymer to be used as general drug delivery systems. It allows on-demand release of incorporated drug is kinetically investigated in real time.
Online spectroscopic monitoring was used to investigate the electrochemically/thermally controlled release behavior of a model drug (naproxen) from drug-doped polypyrrole (DDPPy) film. Avrami's equation has been used to study the kinetics and further analyzing has been carried out using the Arrhenius and the Eyring equations. Furthermore, drug release behavior, with two other electrochemical techniques was investigated.
It was observed both temperature and electrical stimuli increase the rate of release while electrical potential has a greater effect as revealed in the values of release rate constant (from 0.0068 to 0.018 min at 37°C). It was also shown that a linear relationship exists between the applied electrical potentials and release activation parameters.
The electronic properties of the conducting polymer has an important role in release kinetics, there might be a single mechanism with the same limiting step. In addition, it was demonstrated the rate of drug release from DDPPy dramatically depends on the amounts as well as modes of applying potential which provides enhanced control of drug-release kinetics which can be accelerated or even sustained.
研究电化学/温度双刺激响应导电聚合物用作通用药物递送系统的潜力。实时动力学研究其对包封药物的按需释放情况。
采用在线光谱监测法研究模型药物（萘普生）从药物掺杂聚吡咯（DDPPy）膜中的电化学/热控释放行为。利用阿弗拉米方程研究动力学，并使用阿伦尼乌斯方程和艾林方程进行进一步分析。此外，还用另外两种电化学技术研究了药物释放行为。
观察到温度和电刺激均能提高释放速率，而如释放速率常数（37℃下从0.0068至0.018分钟）所示，电势的影响更大。还表明施加的电势与释放活化参数之间存在线性关系。
导电聚合物的电子性质在释放动力学中起重要作用，可能存在具有相同限速步骤的单一机制。此外，证明了从DDPPy释放药物的速率极大地取决于施加电势的量和方式，这提供了对药物释放动力学的增强控制，其可以加速甚至持续。
