Topcul Mehmet, Cetin Idil
Department of Biology, Faculty of Science, Istanbul University, Istanbul, Turkey E-mail :
Asian Pac J Cancer Prev. 2014;15(11):4395-403. doi: 10.7314/apjcp.2014.15.11.4395.
Nowadays there are several limitations in cancer treatment. One of these is the use of conventional medicines which not only target cancer cells and thus also cause high toxicity precluding effective treatment. Recent elucidation of mechanisms that cause cancer has led to discovery of novel key molecules and pathways which have have become successful targets for the treatments that eliminate only cancer cells. These so-called targeted therapies offer new hope for millions of cancer patients, as briefly reveiwed here focusing on different types of agents, like PARP, CDK, tyrosine kinase, farnysyl transferase and proteasome inhibitors, monoclonal antibodies and antiangiogenic agents.
如今癌症治疗存在若干局限性。其中之一是使用传统药物，这些药物不仅靶向癌细胞，因此也会导致高毒性，从而妨碍有效治疗。最近对致癌机制的阐明导致发现了新的关键分子和途径，这些已成为仅消除癌细胞的治疗方法的成功靶点。这些所谓的靶向疗法为数百万癌症患者带来了新希望，在此简要回顾一下不同类型的药物，如聚（ADP-核糖）聚合酶（PARP）、细胞周期蛋白依赖性激酶（CDK）、酪氨酸激酶、法尼基转移酶和蛋白酶体抑制剂、单克隆抗体和抗血管生成药物。
