Ziliotto Silvia, Ogle Olivia, Taylor Kathryn M
Met Ions Life Sci. 2018 Feb 5;18. doi: 10.1515/9783110470734-023.
Zinc is an important element that is gaining momentum as a potential target for cancer therapy. In recent years zinc has been accepted as a second messenger that is now recognized to be able to activate many signalling pathways within a few minutes of an extracellular stimulus by release of zinc(II) from intracellular stores. One of the major effects of this store release of zinc is to inhibit a multitude of tyrosine phosphatases which will prevent the inactivation of tyrosine kinases and hence, encourage further activation of tyrosine kinasedependent signalling pathways. Most of these signalling pathways are not only known to be involved in driving aberrant cancer growth, they are usually the main driving force. All this data together now positions zinc and zinc signalling as potentially important new targets to prevent aggressive cancer growth.
锌是一种重要元素，作为癌症治疗的潜在靶点正日益受到关注。近年来，锌已被公认为第二信使，现已认识到它能够在细胞外刺激后的几分钟内，通过从细胞内储存中释放锌离子（Zn²⁺）来激活许多信号通路。锌从储存中释放的主要作用之一是抑制多种酪氨酸磷酸酶，这将阻止酪氨酸激酶的失活，从而促进酪氨酸激酶依赖性信号通路的进一步激活。这些信号通路中的大多数不仅已知参与驱动异常的癌症生长，而且通常是主要驱动力。所有这些数据共同表明，锌和锌信号传导作为预防侵袭性癌症生长的潜在重要新靶点。
