Olimid Daniel Alin, Florescu Alma Maria, Cernea Daniela, Georgescu Corneliu Cristian, Mărgăritescu Claudiu, Simionescu Cristiana Eugenia, Stepan Alex Emilian
Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania;
Rom J Morphol Embryol. 2014;55(2):363-7.
In this study, we investigated the p16 and Ki67 immunoexpression in 19 ameloblastomas in order to highlight some correlations of these markers with the aggressive variants of tumors. The p16 immunoreaction was present in 90.9% of cases; the highest scores are present in the typical follicular and in the intraluminal unicystic variant, at the opposite pole being the granular cells variant. In these cases, the maximum reaction was observed at the level of the stellated reticulum cells while the lowest reaction was present at the level of cubico-cylindrical peripheral cells of the neoplastic islands. The Ki67 immunoreaction was present in all cases, the highest scores being present in the typical follicular variant, opposite being the ameloblastoma with granular cells cases and that with acanthomatous differentiation type. The immunostained cells were located predominantly at the periphery of the tumoral islands but also in the stellated reticulum cells in the central area. The p16 and Ki67 markers may be useful for distinguishing different types of ameloblastomas in terms of aggressiveness.
在本研究中，我们调查了19例成釉细胞瘤中的p16和Ki67免疫表达情况，以突显这些标志物与肿瘤侵袭性变体之间的一些相关性。p16免疫反应出现在90.9%的病例中；典型滤泡型和管腔内单囊性变体中的得分最高，而颗粒细胞变体则相反。在这些病例中，在星网状细胞水平观察到最大反应，而在肿瘤岛立方柱状外周细胞水平反应最低。Ki67免疫反应存在于所有病例中，典型滤泡型变体中的得分最高，相反的是颗粒细胞型成釉细胞瘤病例和棘皮瘤样分化型病例。免疫染色细胞主要位于肿瘤岛的周边，但也存在于中心区域的星网状细胞中。p16和Ki67标志物在区分不同类型成釉细胞瘤的侵袭性方面可能有用。
