Bologna-Molina Ronell, Mosqueda-Taylor Adalberto, Lopez-Corella Eduardo, de Almeida Oslei Paes, Carrasco-Daza Daniel, Farfán-Morales José E, Molina-Frechero Nelly, Damián-Matsumura Pablo
Department of Biological and Health Sciences, Universidad Autónoma Metropolitana, Mexico.
Pathol Int. 2009 Apr;59(4):229-33. doi: 10.1111/j.1440-1827.2009.02355.x.
The aims of the present study were to examine whether the pattern of syndecan-1 expression correlates with cellular proliferation index in desmoplastic ameloblastomas (DA), peripheral ameloblastomas (PA) and ameloblastic carcinomas (AC), and to compare with that previously reported for solid (SA) and unicystic (UA) variants of ameloblastoma. Immunohistochemistry was performed for syndecan-1 and Ki-67 in seven ameloblastomas (four DA and three PA) and three AC. Expression of syndecan-1 was related to the histological subtype of tumors and, in the case of malignancy, to lower expression levels observed in AC (22.5%) than in PA (47.5%) or DA (77.5%) (P < 0.05). Syndecan-1 expression correlated inversely with Ki-67 proliferative index: the expression was lower in both types of ameloblastomas (1.5% in DA and 6.4% in PA) than in AC (41.2%; P < 0.05). The present results suggest that the decrease in syndecan-1 expression and increase in the Ki-67 index observed in AC is in accordance with its higher aggressiveness as compared to the rare DA and PA. Interestingly, DA had a lower proliferation index as well as the highest levels of syndecan-1 expression. These data suggest that DA differ from the other types of intraosseous ameloblastomas but more studies are necessary to better understand the role of this protein as a marker in the biological behavior of the epithelial odontogenic neoplasms.
本研究的目的是检验在促结缔组织增生性成釉细胞瘤（DA）、外周性成釉细胞瘤（PA）和成釉细胞癌（AC）中，syndecan-1的表达模式是否与细胞增殖指数相关，并与先前报道的成釉细胞瘤实性（SA）和单囊性（UA）变体的情况进行比较。对7例成釉细胞瘤（4例DA和3例PA）和3例AC进行了syndecan-1和Ki-67的免疫组织化学检测。syndecan-1的表达与肿瘤的组织学亚型相关，在恶性肿瘤中，AC（22.5%）中观察到的表达水平低于PA（47.5%）或DA（77.5%）（P<0.05）。syndecan-1表达与Ki-67增殖指数呈负相关：在两种类型的成釉细胞瘤中（DA中为1.5%，PA中为6.4%），其表达均低于AC（41.2%；P<0.05）。目前的结果表明，与罕见的DA和PA相比，AC中syndecan-1表达的降低和Ki-67指数的升高与其更高的侵袭性一致。有趣的是，DA的增殖指数较低，syndecan-1表达水平最高。这些数据表明DA与其他类型的骨内成釉细胞瘤不同，但需要更多研究以更好地理解该蛋白作为上皮性牙源性肿瘤生物学行为标志物的作用。
