Germani Tamara, Zwaigenbaum Lonnie, Bryson Susan, Brian Jessica, Smith Isabel, Roberts Wendy, Szatmari Peter, Roncadin Caroline, Sacrey Lori Ann R, Garon Nancy, Vaillancourt Tracy
Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada,
J Autism Dev Disord. 2014 Dec;44(12):3264-70. doi: 10.1007/s10803-014-2175-x.
This study assessed sensory processing differences between 24-month infants at high-risk of autism spectrum disorder (ASD), each with an older sibling with ASD, and low-risk infants with no family history of ASD. Sensory processing differences were assessed using the Infant/Toddler Sensory Profile, a parent-reported measure. Groups were compared based on 3-year outcomes: (a) high-risk infants subsequently diagnosed with ASD; (b) high-risk infants without an ASD diagnosis; and (c) low-risk infants without an ASD diagnosis. Analyses showed that high-risk infants diagnosed with ASD have more difficulty with auditory processing (i.e., responses to auditory stimuli) and lower registration (i.e., lacking sensation awareness) compared to controls. Thus, behavioral responses to sensory input represent early risk markers of ASD, particularly in high-risk infants.
本研究评估了自闭症谱系障碍（ASD）高危24个月婴儿（每个婴儿都有一个患ASD的哥哥或姐姐）与无ASD家族史的低危婴儿之间的感觉加工差异。使用家长报告的测量工具《婴幼儿感觉概况》评估感觉加工差异。根据3岁时的结果对各组进行比较：（a）随后被诊断为ASD的高危婴儿；（b）未被诊断为ASD的高危婴儿；（c）未被诊断为ASD的低危婴儿。分析表明，与对照组相比，被诊断为ASD的高危婴儿在听觉加工（即对听觉刺激的反应）方面有更多困难，且感觉登记较低（即缺乏感觉意识）。因此，对感觉输入的行为反应是ASD的早期风险标志物，尤其是在高危婴儿中。
