Feldman Maurice A, Hendry Amanda M, Ward Rebecca A, Hudson Melissa, Liu Xudong
Centre for Applied Disability Studies, Brock University, 500 Glenridge Ave., St. Catharines, ON, L2S 3A1, Canada,
J Autism Dev Disord. 2015 May;45(5):1167-75. doi: 10.1007/s10803-014-2277-5.
Identification of early signs of Autism Spectrum Disorder (ASD) could lead to earlier diagnosis and intervention. This cross-sectional study used the Parent Observation of Early Markers Scale (POEMS, Feldman et al. in J Autism Dev Disord 42:13-12, 2012) to identify early signs of ASD in 69 ASD high-risk (older sibling diagnosed with ASD) and 69 sex and aged-matched ASD low-risk second-born or later infants (no family history of ASD) between 6 and 36 months of age. Family sociodemographic comparisons were also made between the risk groups. The high-risk children had significantly more elevated POEMS items than the low-risk children at 12, 18, 24, 30 and 36 months of age, even when the children subsequently diagnosed with ASD were removed from the analyses. Families of the high-risk group had older parents, lower family income and fewer mothers working out of the home than the low-risk group. These sociodemographic variables were not significantly correlated with POEMS scores. The results suggest that high-risk infants may show signs of the broader ASD phenotype as early as 12 months of age that may be unrelated to observed sociodemographic family differences.
识别自闭症谱系障碍（ASD）的早期迹象有助于实现更早的诊断和干预。这项横断面研究使用了早期指标父母观察量表（POEMS，费尔德曼等人，《自闭症与发育障碍杂志》，2012年，第42卷，第13 - 12页），以识别69名ASD高风险（年长同胞被诊断为ASD）以及69名年龄和性别匹配的ASD低风险次胎或更晚出生的婴儿（无ASD家族史）在6至36个月大时的ASD早期迹象。研究还对风险组之间的家庭社会人口统计学进行了比较。在12、18、24、30和36个月大时，高风险儿童的POEMS项目得分显著高于低风险儿童，即使在分析中剔除了随后被诊断为ASD的儿童也是如此。与低风险组相比，高风险组家庭的父母年龄更大、家庭收入更低，外出工作的母亲更少。这些社会人口统计学变量与POEMS得分无显著相关性。结果表明，高风险婴儿可能早在12个月大时就表现出更广泛的ASD表型迹象，这可能与观察到的社会人口统计学家庭差异无关。
