SLRP Associates Consultation in Biotechnology, 572 Cabot Hill Road, Bridgewater, NJ 08807, USA.
Biomolecules. 2013 Oct 2;3(4):741-77. doi: 10.3390/biom3040741.
Chirality is a key factor in the safety and efficacy of many drug products and thus the production of single enantiomers of drug intermediates and drugs has become increasingly important in the pharmaceutical industry. There has been an increasing awareness of the enormous potential of microorganisms and enzymes derived there from for the transformation of synthetic chemicals with high chemo-, regio- and enatioselectivities. In this article, biocatalytic processes are described for the synthesis of chiral alcohols and unntural aminoacids for pharmaceuticals.
手性是许多药物产品安全性和有效性的关键因素，因此，药物中间体和药物单一对映异构体的生产在制药行业变得越来越重要。人们越来越意识到微生物和酶的巨大潜力，可以高化学选择性、区域选择性和对映选择性转化合成化学品。本文描述了用于合成手性醇和药物中天然氨基酸的生物催化过程。
