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条斑紫菜肽诱导细胞凋亡：对MCF-7细胞中胰岛素样生长因子I受体信号通路的调控

Induction of apoptosis by a peptide from Porphyra yezoensis: regulation of the insulin-like growth factor I receptor signaling pathway in MCF-7 cells.

作者信息

Park Su-Jin, Ryu Jina, Kim In-Hye, Choi Youn-Hee, Nam Taek-Jeong

机构信息

Department of Food and Science, Pukyong National University, Busan 608-737, Republic of Korea.

Institute of Fisheries Science, Pukyong National University, Busan 619-911, Republic of Korea.

出版信息

Int J Oncol. 2014 Sep;45(3):1011-6. doi: 10.3892/ijo.2014.2509. Epub 2014 Jun 20.

DOI:10.3892/ijo.2014.2509
PMID:24970277
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4121416/
Abstract

This study examined how PPY, a peptide from Porphyra yezoensis, regulates multiple cell growth-related signaling pathways in MCF-7 cells. This study determined that PPY induces cell cycle arrest and inhibits the IGF-IR signaling pathway. Cell proliferation studies revealed that PPY induced cell death in a dose-dependent manner. Expression levels of IGF-IR were decreased in MCF-7 cells by PPY in a dose‑dependent manner. These results indicate that inhibition of the IGF-IR pathway is also involved in PPY induced proliferation of MCF-7 cells. In addition, these data demonstrated that PPY induces cell cycle arrest and activates apoptosis.

摘要

本研究考察了来自条斑紫菜的一种肽——紫菜肽（PPY）如何调节MCF-7细胞中多个与细胞生长相关的信号通路。本研究确定PPY可诱导细胞周期停滞并抑制胰岛素样生长因子-1受体（IGF-IR）信号通路。细胞增殖研究表明，PPY以剂量依赖的方式诱导细胞死亡。PPY使MCF-7细胞中IGF-IR的表达水平呈剂量依赖性降低。这些结果表明，IGF-IR通路的抑制也参与了PPY诱导的MCF-7细胞增殖。此外，这些数据证明PPY可诱导细胞周期停滞并激活细胞凋亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c23/4121416/5ff48500fa7b/IJO-45-03-1011-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c23/4121416/dd6232eec2a2/IJO-45-03-1011-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c23/4121416/ceeb3cd5b24c/IJO-45-03-1011-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c23/4121416/3d81605e588b/IJO-45-03-1011-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c23/4121416/769039be7405/IJO-45-03-1011-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c23/4121416/37e41dd9c6ba/IJO-45-03-1011-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c23/4121416/79422a6192ae/IJO-45-03-1011-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c23/4121416/d827bb2d1388/IJO-45-03-1011-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c23/4121416/5ff48500fa7b/IJO-45-03-1011-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c23/4121416/dd6232eec2a2/IJO-45-03-1011-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c23/4121416/ceeb3cd5b24c/IJO-45-03-1011-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c23/4121416/3d81605e588b/IJO-45-03-1011-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c23/4121416/769039be7405/IJO-45-03-1011-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c23/4121416/37e41dd9c6ba/IJO-45-03-1011-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c23/4121416/79422a6192ae/IJO-45-03-1011-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c23/4121416/d827bb2d1388/IJO-45-03-1011-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c23/4121416/5ff48500fa7b/IJO-45-03-1011-g07.jpg

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