Kulkarni J, Lalitha V S, Bhide S
Carcinogenesis Division, Tata Memorial Centre, Bombay, India.
J Cancer Res Clin Oncol. 1989;115(2):166-9. doi: 10.1007/BF00397918.
Two commonly used varieties of masheri, pyrolysed tobacco products, were tested for their skin carcinogenicity in Swiss mice and the more sensitive strain of Swiss bare mice. In Swiss mice, painting of brown and black varieties of masheri extract did not show any tumorgenic effect; however, a marginal synergistic effect of 7,12-dimethylbenz[a]anthracene (DMBA) and black masheri extract was observed when DMBA was used as an initiator. In Swiss bare mice, black masheri extract induced tumors in 20%-35% animals at both the doses tested. In an initiation/promotion protocol with DMBA as an initiator, induction of tumors in 50%-52% Swiss bare mice and a slight synergistic effect of black masheri extract were observed with a low dose of DMBA, suggesting a synergistic effect.
对两种常用的masheri（热解烟草产品）品种在瑞士小鼠和更敏感的瑞士裸鼠品系中进行了皮肤致癌性测试。在瑞士小鼠中，涂抹棕色和黑色品种的masheri提取物未显示出任何致癌作用；然而，当使用7,12-二甲基苯并[a]蒽（DMBA）作为引发剂时，观察到DMBA与黑色masheri提取物有轻微的协同作用。在瑞士裸鼠中，黑色masheri提取物在两个测试剂量下均在20%-35%的动物中诱发了肿瘤。在以DMBA作为引发剂的启动/促进实验方案中，使用低剂量DMBA时，在50%-52%的瑞士裸鼠中观察到肿瘤诱发以及黑色masheri提取物有轻微的协同作用，表明存在协同效应。
