Department of Cardiology, Seyyed-al-Shohada Heart Center, Urmia University of Medical Sciences, Urmia, Iran.
Seyyed-al-Shohada Heart Center, Urmia University of Medical Sciences, Urmia, Iran.
Int J Gen Med. 2014 Jun 19;7:303-9. doi: 10.2147/IJGM.S64812. eCollection 2014.
Vitamin D has been shown to have an anticoagulant effect. A decrease in 25-hydroxyvitamin D [25(OH)D] concentration has also been associated with an increased risk of venous thromboembolism. Hence, we sought to determine the relationship between 25(OH) D levels and idiopathic lower-extremity deep vein thrombosis (DVT).
In a case control study, a total of 82 participants with idiopathic lower-extremity DVT were enrolled along with 85 sex- and age-matched healthy participants as controls. The plasma 25(OH)D levels were measured in all the studied samples.
The participants' mean age was 47.1±12.3 years. Baseline characteristics were not significantly different between the groups. The concentration of 25(OH)D was significantly lower in the DVT group compared to that of the control group (17.9±10.3 versus 23.1±12.5 ng/mL, P=0.004). The prevalence of participants with deficient 25(OH)D levels was significantly higher in the both DVT and control groups than those with sufficient 25(OH)D levels (68.3% versus 13.4%, and 49.4% versus 28.2%, respectively, P=0.027). In a multivariate analysis, 25(OH)D levels and sex were found to be the only independent predictors of DVT (odds ratio [OR] 1.05, 95% confidence interval [CI] 1.02-1.08, P=0.001 and OR 0.51, 95% CI 0.26-1.00, P=0.049, respectively).
Low levels of 25(OH)D are associated with idiopathic lower-extremity DVT. Further investigation is needed to establish determinants and probable causative role of 25(OH)D.
维生素 D 具有抗凝作用。25-羟维生素 D [25(OH)D]浓度的降低也与静脉血栓栓塞风险的增加有关。因此，我们试图确定 25(OH)D 水平与特发性下肢深静脉血栓形成（DVT）之间的关系。
在一项病例对照研究中，共纳入 82 例特发性下肢 DVT 患者和 85 名性别和年龄匹配的健康对照者。所有研究样本均测量血浆 25(OH)D 水平。
参与者的平均年龄为 47.1±12.3 岁。两组间基线特征无显著差异。与对照组相比，DVT 组 25(OH)D 浓度明显较低（17.9±10.3 与 23.1±12.5ng/mL，P=0.004）。两组中缺乏 25(OH)D 水平的患者比例均明显高于有足够 25(OH)D 水平的患者（68.3%比 13.4%和 49.4%比 28.2%，分别，P=0.027）。多变量分析发现，25(OH)D 水平和性别是 DVT 的唯一独立预测因素（比值比[OR]1.05，95%置信区间[CI]1.02-1.08，P=0.001 和 OR 0.51，95%CI 0.26-1.00，P=0.049）。
低水平的 25(OH)D 与特发性下肢 DVT 相关。需要进一步研究以确定 25(OH)D 的决定因素和可能的因果作用。
