Department of Otolaryngology, Stanford University School of Medicine Stanford, CA, USA.
Department of Otolaryngology, Stanford University School of Medicine Stanford, CA, USA ; Department of Molecular and Cellular Physiology, Stanford University School of Medicine Stanford, CA, USA.
Front Cell Neurosci. 2014 Jun 12;8:162. doi: 10.3389/fncel.2014.00162. eCollection 2014.
Intracellular calcium stores control many neuronal functions such as excitability, gene expression, synaptic plasticity, and synaptic release. Although the existence of calcium stores along with calcium-induced calcium release (CICR) has been demonstrated in conventional and ribbon synapses, functional significance and the cellular mechanisms underlying this role remains unclear. This review summarizes recent experimental evidence identifying contribution of CICR to synaptic transmission and synaptic plasticity in the CNS, retina and inner ear. In addition, the potential role of CICR in the recruitment of vesicles to releasable pools in hair-cell ribbon synapses will be specifically discussed.
细胞内钙库控制着许多神经元功能，如兴奋性、基因表达、突触可塑性和突触释放。尽管已经在常规和带状突触中证明了钙库的存在以及钙诱导钙释放（CICR），但其在该作用中的功能意义和细胞机制仍不清楚。本综述总结了最近的实验证据，这些证据确定了 CICR 对中枢神经系统、视网膜和内耳中突触传递和突触可塑性的贡献。此外，还将专门讨论 CICR 在毛细胞带状突触中募集可释放囊泡到可释放池中的潜在作用。
