Foroozanfard Fatemeh, Moosavi Seyed Gholam Abbas, Mansouri Fariba, Bazarganipour Fatemeh
Gynecology and Obstetrics Department, Kashan University of Medical Sciences, Kashan, Iran.
Biostatistics Department, Kashan University of Medical Sciences, Kashan, Iran.
J Family Reprod Health. 2014 Mar;8(1):7-12.
There are some metabolic similarities between women with gestational diabetes mellitus (GDM) and polycystic ovary syndrome (PCOS); it is still uncertain, however, to what extent coexistence GDM and PCOS affects pregnancy outcome. The present study was designed to determine the obstetric and neonatal outcome in PCOS with GDM.
A case-control study was conducted involving 261 GDM women. Thirty hundred-one cases had PCOS based on Rotterdam criteria and the other thirty hundred cases (control group) were women without PCOS. The subjects in each group were evaluated regarding obstetric and those women whose documentation's were complete entered the study.
In present study, women with PCOS and GDM had more than twofold increased odds of preeclampsia (p = 0.003, CI = 1.56-5.01, and OR = 2.8) and PIH (p= 0.04, CI = 1.28-4.5, and OR= 2.4). Maternal PCOS and GDM were also associated with threefold increased odds of neonatal hypoglycemia (p= 0.004, CI= 1.49-6.58, and OR= 3.13).
Our finding emphasized that pregnant PCOS patients should be followed carefully for the occurrence of various pregnancy and neonatal complications including hypertension and hypoglycemia. We suggested that these neonates should be given more care regarding hypoglycemia symptoms.
妊娠糖尿病（GDM）女性与多囊卵巢综合征（PCOS）女性存在一些代谢相似性；然而，GDM与PCOS并存对妊娠结局的影响程度仍不确定。本研究旨在确定合并GDM的PCOS患者的产科和新生儿结局。
进行了一项病例对照研究，纳入261例GDM女性。根据鹿特丹标准，301例患有PCOS，另外300例（对照组）为无PCOS的女性。对每组受试者进行产科评估，记录完整的女性纳入研究。
在本研究中，合并PCOS和GDM的女性发生先兆子痫的几率增加了两倍多（p = 0.003, CI = 1.56 - 5.01, OR = 2.8），发生妊娠高血压（PIH）的几率也增加了两倍多（p = 0.04, CI = 1.28 - 4.5, OR = 2.4）。母亲患有PCOS和GDM还与新生儿低血糖几率增加三倍有关（p = 0.004, CI = 1.49 - 6.58, OR = 3.13）。
我们的研究结果强调，对于合并PCOS的孕妇，应密切关注包括高血压和低血糖在内的各种妊娠和新生儿并发症的发生。我们建议应对这些新生儿的低血糖症状给予更多关注。
