Eckardt A, Pogrel M A, Kaban L B, Chew K, Mayall B H
Department of Oral and Maxillofacial Surgery, University of California San Francisco, School of Dentistry.
Int J Oral Maxillofac Surg. 1989 Feb;18(1):3-6. doi: 10.1016/s0901-5027(89)80004-9.
Giant cell nuclear DNA, in 30 giant cell lesions of the jaws, was quantified by computer-assisted image analysis. DNA content was then used to predict clinical behavior and outcome. 4 nuclei in each of 25 giant cells (total = 100 nuclei) were randomly selected and the DNA content was quantified by the Leitz Texture-Analysis-System-Plus. DNA in nuclei of normal appearing stromal fibroblasts (n = 20) was similarly measured. The DNA index was calculated as the mean nuclear DNA content of giant cells divided by the mean DNA content of control fibroblasts. The mean DNA-index of aggressive lesions (1.09, SD = 0.12) was not significantly different from that of non-aggressive lesions (1.18, SD = 0.15) (p = 0.093). The results indicate that the nuclear DNA content of giant cells is not useful as a predictor of the clinical behavior of giant cell lesions of the jaws.
通过计算机辅助图像分析对30例颌骨巨细胞病变中的巨细胞核DNA进行定量分析。然后将DNA含量用于预测临床行为和结果。从25个巨细胞中的每一个中随机选择4个细胞核（共100个细胞核），并使用Leitz纹理分析系统升级版对DNA含量进行定量分析。对外观正常的基质成纤维细胞（n = 20）的细胞核中的DNA进行类似测量。DNA指数计算为巨细胞的平均核DNA含量除以对照成纤维细胞的平均DNA含量。侵袭性病变的平均DNA指数（1.09，标准差= 0.12）与非侵袭性病变的平均DNA指数（1.18，标准差= 0.15）无显著差异（p = 0.093）。结果表明，巨细胞核DNA含量不能作为颌骨巨细胞病变临床行为的预测指标。
