小鼠Vκ基因的表达并不遵循VH模式。
Murine V kappa gene expression does not follow the VH paradigm.
作者信息
Kaushik A, Schulze D H, Bona C, Kelsoe G
机构信息
Department of Microbiology, Mount Sinai School of Medicine, New York 10029.
出版信息
J Exp Med. 1989 May 1;169(5):1859-64. doi: 10.1084/jem.169.5.1859.
Abstract
V kappa gene family expression among LPS-reactive murine B lymphocytes, unlike that of VH gene families, is not proportional to genomic complexity, i.e., nonstoichiometric. Furthermore, no positional bias for the overexpression of J-proximal V kappa genes (V kappa 21) is observed among neonatal B lymphocytes. Yet, the V kappa 1 and V kappa 9 families located in the center of V kappa locus are preferentially used by neonatal B splenocytes. Thus, the mechanisms of V kappa gene rearrangement and expression appear to differ significantly from those controlling the VH locus.
摘要
与VH基因家族不同，LPS反应性小鼠B淋巴细胞中的Vκ基因家族表达与基因组复杂性不成比例，即非化学计量的。此外，在新生B淋巴细胞中未观察到J近端Vκ基因（Vκ21）过表达的位置偏向性。然而，位于Vκ基因座中心的Vκ1和Vκ9家族优先被新生B脾细胞使用。因此，Vκ基因重排和表达的机制似乎与控制VH基因座的机制有显著差异。
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