Wang Hai, Zhang Qian, Fang Xiangdong
CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China.
Front Med. 2014 Dec;8(4):433-44. doi: 10.1007/s11684-014-0336-0. Epub 2014 Jun 27.
Stem cells are capable of self-renewal and differentiation, and the processes regulating these events are among the most comprehensively investigated topics in life sciences. In particular, the molecular mechanisms of the self-renewal, proliferation, and differentiation of stem cells have been extensively examined. Multi-omics integrative analysis, such as transcriptomics combined with proteomics, is one of the most promising approaches to the systemic investigation of stem cell biology. We reviewed the available information on stem cells by examining published results using transcriptomic and proteomic characterization of the different stem cell processes. Comprehensive understanding of these important processes can only be achieved using a systemic methodology, and employing such method will strengthen the study on stem cell biology and promote the clinical applications of stem cells.
干细胞具有自我更新和分化的能力，而调控这些过程的机制是生命科学中研究最为全面的课题之一。特别是，干细胞自我更新、增殖和分化的分子机制已经得到了广泛研究。多组学整合分析，如转录组学与蛋白质组学相结合，是系统研究干细胞生物学最具前景的方法之一。我们通过检查已发表的关于不同干细胞过程的转录组学和蛋白质组学特征的结果，回顾了有关干细胞的现有信息。只有使用系统方法才能全面理解这些重要过程，采用这种方法将加强干细胞生物学的研究，并促进干细胞的临床应用。
