Department of Ultrasound in Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R.China.
State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai 200050, P.R.China.
Biomaterials. 2014 Sep;35(28):8197-205. doi: 10.1016/j.biomaterials.2014.06.010. Epub 2014 Jun 25.
A multifunctional organic-inorganic hybrid nanocapsule based on Bi2S3-embedded poly (lactic-co-glycolic acid) (PLGA) nanocapsule has been elaborately designed to combine the merits of both polymeric shell structure and Bi2S3 nanoparticles. Hydrophobic Bi2S3 nanoparticles were successfully introduced into the PLGA nanocapsules via a facile and efficient water/oil/water (W/O/W) emulsion strategy. The elastic polymeric PLGA shell provides the excellent capability of ultrasound contrast imaging to the Bi2S3/PLGA. Meanwhile, the potential of these microcapsules to enhance the high intensity focused ultrasound (HIFU) therapy was demonstrated. Importantly, this research provided the first example of both in vitro and in vivo to demonstrate the radiosensitization effect of Bi2S3-embedded PLGA hybrid nanocapsules against prostate cancer under external X-ray irradiation. Thus, the successful integration of the Bi2S3 and PLGA nanocapsules provided an alternative strategy for the highly efficient ultrasound guided HIFU/RT synergistic therapy.
一种基于 Bi2S3 嵌入聚（乳酸-共-乙醇酸）（PLGA）纳米胶囊的多功能有机-无机杂化纳米胶囊已被精心设计，将聚合壳结构和 Bi2S3 纳米粒子的优点结合在一起。疏水性 Bi2S3 纳米粒子通过简便有效的水/油/水（W/O/W）乳液策略成功引入到 PLGA 纳米胶囊中。弹性聚合物 PLGA 壳为 Bi2S3/PLGA 提供了出色的超声对比成像能力。同时，还证明了这些微胶囊增强高强度聚焦超声（HIFU）治疗的潜力。重要的是，这项研究提供了首例体外和体内研究结果，证明了在外部 X 射线照射下，嵌入 PLGA 杂化纳米胶囊的 Bi2S3 对前列腺癌的放射增敏作用。因此，Bi2S3 和 PLGA 纳米胶囊的成功整合为高效超声引导 HIFU/RT 协同治疗提供了一种替代策略。
