Chen Rui, Zhou Ruyi, Qiao Jiyan, Yang Yanan, Zhou Xingfan, Bai Ru, Wang Yuqian, Yan Liang, Wu Chongming
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety & CAS Center for Excellence in Nanoscience, National Center for Nanoscience & Technology of China, Beijing, 100190, PR China.
Beijing Key Laboratory of Occupational Safety and Health, Institute of Urban Safety and Environmental Science, Beijing Academy of Science and Technology, Beijing, 100054, PR China.
Mater Today Bio. 2021 Dec 2;13:100178. doi: 10.1016/j.mtbio.2021.100178. eCollection 2022 Jan.
Effective and safe contrast agents for X-ray computed tomography (CT) imaging of the gastrointestinal (GI) tract are quite desirable for realizing high diagnostic accuracy and low toxicity in the clinic. Herein, we synthesize a series of silica-coated bismuth sulfide core-shell nanomaterials (BiS@SiO) of various sizes and systematically study their GI CT contrast performance and potential toxic effects in comparison with those of barium sulfate (BaSO) in mice. The experimental results suggest that these BiS@SiO core-shell nanomaterials display superior CT contrast performance and higher elimination efficacy than BaSO by single-dose exposure manner (10 mg/kg Bi element/b.w. for BiS@SiO versus 30 mg/kg Ba element/b.w. for BaSO). Furthermore, 28 days after exposure, BiS@SiO core-shell nanomaterials show minimal toxic effects and nonsignificant influences on the structure and function of the gut microbiota in mice. This demonstrates that no adverse effects on the gut homeostasis are induced by BiS@SiO core-shell nanomaterials and, thus, suggests that they can act as excellent and safe CT contrast agents for GI tract imaging.
在临床中，为实现高诊断准确性和低毒性，非常需要有效且安全的胃肠道（GI）X射线计算机断层扫描（CT）成像造影剂。在此，我们合成了一系列不同尺寸的二氧化硅包覆硫化铋核壳纳米材料（BiS@SiO），并与硫酸钡（BaSO）对比，系统研究了它们在小鼠体内的胃肠道CT造影性能和潜在毒性作用。实验结果表明，通过单剂量暴露方式（BiS@SiO为10毫克/千克铋元素/体重，BaSO为30毫克/千克钡元素/体重），这些BiS@SiO核壳纳米材料比BaSO表现出更优异的CT造影性能和更高的清除效率。此外，暴露28天后，BiS@SiO核壳纳米材料对小鼠肠道微生物群的结构和功能显示出最小的毒性作用和不显著的影响。这表明BiS@SiO核壳纳米材料不会对肠道稳态产生不良影响，因此表明它们可作为用于胃肠道成像的优异且安全的CT造影剂。
