British Columbia Centre for Disease Control University of British Columbia, Vancouver.
British Columbia Centre for Disease Control.
J Infect Dis. 2015 Jan 1;211(1):109-14. doi: 10.1093/infdis/jiu366. Epub 2014 Jun 27.
To understand the epidemic resurgence of influenza due to the 2009 pandemic influenza A(H1N1) strain (A[H1N1]pdm09) during the 2013-2014 influenza season, we compared age-related cross-sectional estimates of seroprotection before the pandemic (during 2009) and after the pandemic (during 2010 and 2013) to subsequent surveillance-based, laboratory-confirmed incidence of influenza due to A(H1N1)pdm09 in British Columbia, Canada. Prepandemic seroprotection was negligible except for very old adults (defined as adults aged ≥ 80 years), among whom 80% had seroprotection. Conversely, postpandemic seroprotection followed a U-shaped distribution, with detection in approximately 35%-45% of working-aged adults but in ≥ 70% of very old adults and young children, excluding children aged <5 years in 2013, among whom seroprotection again decreased to <20%. The incidence was 5-fold higher during 2013-2014, compared with 2010-2011, and was highest among children aged <5 years and working-aged adults, reflecting a mirror image of the age-based seroprotection data.
为了了解 2009 年大流行的甲型 H1N1 流感（A[H1N1]pdm09）在 2013-2014 年流感季节引起的流感疫情反弹，我们比较了大流行前（2009 年）和大流行后（2010 年和 2013 年）与随后基于监测的、经实验室确认的由 A(H1N1)pdm09 引起的流感在加拿大不列颠哥伦比亚省的年龄相关横断面估计血清保护率。除了非常老的成年人（定义为年龄≥80 岁的成年人）外，大流行前的血清保护率可以忽略不计，其中 80%的人有血清保护。相反，大流行后的血清保护率呈 U 形分布，约有 35%-45%的成年工作人群具有血清保护，而≥70%的非常老的成年人和幼儿具有血清保护，2013 年除外，其中 5 岁以下儿童的血清保护率再次下降至<20%。与 2010-2011 年相比，2013-2014 年的发病率高了 5 倍，发病率最高的是 5 岁以下儿童和成年工作人群，这反映了年龄相关血清保护数据的镜像。
