美沙拉嗪治疗模仿儿童溃疡性结肠炎的复发。
Mesalamine treatment mimicking relapse in a child with ulcerative colitis.
机构信息
Referral Center for Pediatric Gastroenterology and Nutrition, Children's Hospital Zagreb, Zagreb, Croatia,
出版信息
World J Pediatr. 2014 Nov;10(4):371-3. doi: 10.1007/s12519-014-0485-x. Epub 2014 Jun 28.
BACKGROUND
There are reports on mesalamine-induced bloody diarrhea mimicking ulcerative colitis (UC) relapse, mostly in adults.
METHODS
Herein we present a case of a child with UC who developed relapse of hemorrhagic colitis related to mesalamine.
RESULTS
A 10-year-old girl developed severe symptoms mimicking UC relapse 3 weeks after introduction of mesalamine therapy. After mesalamine was withdrawn, her symptoms improved, but deteriorated again during the challenge of mesalamine despite concomitant use of corticosteroids.
CONCLUSION
This is the first case report on such a young child during the concomitant use of corticosteroids.
背景
有报道称美沙拉嗪可引起类似溃疡性结肠炎（UC）复发的血性腹泻，这种情况大多见于成人。
方法
本文报告了一例儿童 UC 患者在使用美沙拉嗪后发生与美沙拉嗪相关的出血性结肠炎复发。
结果
一名 10 岁女孩在开始使用美沙拉嗪治疗 3 周后出现严重症状，类似 UC 复发。停用美沙拉嗪后，症状改善，但在同时使用皮质类固醇的情况下，美沙拉嗪再次激发试验时症状再次恶化。
结论
这是首例在同时使用皮质类固醇的情况下报道如此年幼患儿的病例。
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