St John's Medical College Hospital, Bengaluru, India
St John's Medical College Hospital, Bengaluru, India.
Clin Med (Lond). 2023 Mar;23(2):173-174. doi: 10.7861/clinmed.2022-0431.
A 45-year-old woman presented to the hospital with bloody diarrhoea and significant weight loss over the past 1 month. On admission and evaluation, she was found to have acute ulcerative colitis. She was started on prednisolone and mesalamine therapy. Within 24 hours of initiation of this therapy, the patient complained of giddiness and chest discomfort and was found to have sinus bradycardia on ECG with no acute coronary event. After withdrawing mesalamine, her heart rate normalised within 24 hours and she remained symptom-free. This is a rare case report of severe symptomatic sinus bradycardia due to mesalamine therapy; to our knowledge, only four cases of mesalamine-induced bradycardia have been reported in the literature.
一位 45 岁女性因血便和过去 1 个月明显体重减轻而到医院就诊。入院和评估时，发现她患有急性溃疡性结肠炎。她开始接受泼尼松龙和美沙拉嗪治疗。在开始这种治疗的 24 小时内，患者主诉头晕和胸部不适，心电图显示窦性心动过缓，但无急性冠状动脉事件。停用美沙拉嗪后，她的心率在 24 小时内恢复正常，且无任何症状。这是一例因美沙拉嗪治疗而导致严重症状性窦性心动过缓的罕见病例报告；据我们所知，文献中仅报道了 4 例美沙拉嗪引起的心动过缓。
