Lebedev V P
Ter Arkh. 1989;61(1):86-90.
Gastric secretion was evaluated in 821 male inpatients aged 18-55 years with unaffected gastrointestinal, nervous and endocrine systems. With age, there was a tendency to increasing manufacture of gastric juice, hydrochloric acid, pepsin and gastric mucoprotein in 70% of the examinees. Reaching its maximum at the age of 25, the secretion remained stable for the following 15 years, progressively reducing thereafter. To the age of 50 gastric secretion diminished by 16.7%, the parameters lowing in the following order: volume of secretion, concentrations of hydrochloric acid, pepsin, gastric mucoprotein From the onset of physiological involution of the gastric glands observed usually at the age of 40 the response of the glands to reflex intestinal stimuli fell (explanation for basal secretion reduction), while that to humoral stimuli rose (cabbage-water). Hyposecretion may be, however, observed early in adolescence (10% of the examinees) and hypersecretion in middle life (20% of the examinees over 50). The results are thought helpful in clinical practice, occupational selection and mass health examinations of the population.
对821名年龄在18至55岁之间、胃肠、神经和内分泌系统未受影响的男性住院患者的胃分泌情况进行了评估。随着年龄增长，70%的受检者胃液、盐酸、胃蛋白酶和胃粘蛋白的分泌量有增加趋势。分泌量在25岁时达到峰值，随后15年保持稳定，之后逐渐减少。到50岁时，胃分泌量减少了16.7%，各项参数下降顺序为：分泌量、盐酸浓度、胃蛋白酶、胃粘蛋白。从通常在40岁时观察到的胃腺生理性退化开始，腺体对反射性肠道刺激的反应下降（基础分泌减少的原因），而对体液刺激的反应增强（白菜汁）。然而，青春期早期可能出现分泌不足（10%的受检者），中年时可能出现分泌过多（50岁以上受检者的20%）。这些结果被认为对临床实践、职业选择和人群大规模健康检查有帮助。
