Department of Neurosciences, Center for Clinical Psychiatry, KU Leuven, Leuven, Belgium.
University Psychiatric Center, KU Leuven, Kortenberg, Belgium.
Front Endocrinol (Lausanne). 2020 Oct 9;11:573479. doi: 10.3389/fendo.2020.573479. eCollection 2020.
People with serious mental illness (SMI), including schizophrenia, bipolar disorder, and major depressive disorder, have a higher mortality rate and shortened life expectancy. This is mainly attributable to physical diseases, particularly cardiovascular diseases (CVDs). Important risk factors for CVDs are obesity and other metabolic abnormalities, which are especially prevalent in people with SMI. Several factors contribute to this increased risk, including unhealthy lifestyles. Psychotropic medication independently further increases this risk. In this review we want to examine the relationship between obesity and other components of the metabolic syndrome and psychotropic medication in people with SMI.
患有严重精神疾病（SMI）的人，包括精神分裂症、双相情感障碍和重度抑郁症，其死亡率更高，预期寿命更短。这主要归因于身体疾病，特别是心血管疾病（CVD）。心血管疾病的重要危险因素包括肥胖和其他代谢异常，这些在患有 SMI 的人群中尤为普遍。有几个因素导致了这种风险增加，包括不健康的生活方式。精神药物的使用独立地进一步增加了这种风险。在这篇综述中，我们想研究肥胖症和代谢综合征的其他成分以及精神药物在患有 SMI 的人群中的关系。
