射血分数保留的心力衰竭的病因及病理生理学
Causes and pathophysiology of heart failure with preserved ejection fraction.
作者信息
Kovács Árpád, Papp Zoltán, Nagy László
机构信息
Division of Clinical Physiology, Faculty of Medicine, Institute of Cardiology, University of Debrecen, Móricz Zs. krt. 22, Debrecen 4032, Hungary.
Division of Clinical Physiology, Faculty of Medicine, Institute of Cardiology, University of Debrecen, Móricz Zs. krt. 22, Debrecen 4032, Hungary.
出版信息
Heart Fail Clin. 2014 Jul;10(3):389-98. doi: 10.1016/j.hfc.2014.04.002. Epub 2014 May 22.
Heart failure with preserved ejection fraction (HFPEF) is frequently associated with multiple disorders complicating both the clinical management and the understanding of the underlying mechanisms. This review focuses on the causes and pathophysiology of HFPEF and overviews how cellular and molecular changes related to various comorbidities may influence the age-dependent and gender-dependent hemodynamic alterations of diastolic ventricular function.
射血分数保留的心力衰竭（HFpEF）常与多种疾病相关，这使得临床管理和对潜在机制的理解都变得复杂。本综述聚焦于HFpEF的病因和病理生理学，并概述与各种合并症相关的细胞和分子变化如何影响舒张期心室功能的年龄依赖性和性别依赖性血流动力学改变。
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