de Carvalho Rocha Heraldo Arcela, Dantas Bruna Priscilla Vasconcelos, Rolim Thaísa Leite, Costa Bagnólia Araújo, de Medeiros Arnaldo Correia
Health Sciences Center (Heraldo Arcela de Carvalho Rocha, Bruna Priscilla Vasconcelos Dantas, Thaísa Leite Rolim, Bagnólia Araújo Costa), Federal University of Paraíba, Cidade Universitária, Campus I, João Pessoa, PB, Brazil ; Medical Sciences Center (Heraldo Arcela de Carvalho Rocha, Arnaldo Correira de Medeiros), Federal University of Paraíba, Cidade Universitária, Campus I, João Pessoa, PB, Brazil.
Health Sciences Center (Heraldo Arcela de Carvalho Rocha, Bruna Priscilla Vasconcelos Dantas, Thaísa Leite Rolim, Bagnólia Araújo Costa), Federal University of Paraíba, Cidade Universitária, Campus I, João Pessoa, PB, Brazil.
Ann Gastroenterol. 2014;27(3):200-206.
Irritable bowel syndrome (IBS) is a very frequent functional gastrointestinal disorder characterized by recurrent abdominal pain or discomfort and alteration of bowel habits. The IBS physiopathology is extremely complex. Visceral hypersensitivity plays an important role in the pathogenesis of abdominal pain in both and models of this functional disorder. In order to obtain a general view of the participation of the main ion channels and receptors regarding the visceral hypersensitivity in the IBS and to describe their chemical structure, a literature review was carried out. A bibliographical research in the following electronic databases: Pubmed and Virtual Library in Health (BVS) was fulfilled by using the search terms "ion channels" "or" "receptors" "and" "visceral hypersensitivity" "or" "visceral nociception" "and" "irritable bowel syndrome". Original and review articles were considered for data acquisition. The activation of the ATP ion-gated channels, voltage-gated sodium (Na) and calcium (Ca) channels, as well as the activation of protease-activated receptors (PAR2), transient receptor potential vanilloide-1, serotonin, cannabinoids and cholecystokinin are involved in the genesis of visceral hypersensitivity in IBS. The involvement of ion channels and receptors concerning visceral hypersensitivity is noteworthy in IBS models.
肠易激综合征（IBS）是一种非常常见的功能性胃肠疾病，其特征为反复出现的腹痛或不适以及排便习惯改变。IBS的病理生理学极其复杂。在内脏超敏反应在这种功能性疾病的两种动物模型的腹痛发病机制中均起重要作用。为了全面了解IBS中与内脏超敏反应相关的主要离子通道和受体的参与情况并描述其化学结构，我们进行了一项文献综述。通过使用搜索词“离子通道”“或”“受体”“和”“内脏超敏反应”“或”“内脏伤害感受”“和”“肠易激综合征”，在以下电子数据库中进行了文献检索：PubMed和健康虚拟图书馆（BVS）。原始文章和综述文章均被纳入数据收集范围。ATP离子门控通道、电压门控钠（Na）通道和钙（Ca）通道的激活，以及蛋白酶激活受体（PAR2）、瞬时受体电位香草酸受体-1、5-羟色胺、大麻素和胆囊收缩素的激活均参与了IBS内脏超敏反应的发生。在IBS模型中，离子通道和受体与内脏超敏反应的相关性值得关注。
