发展的可塑性：表观遗传学知识如何促进对饮食失调的理解。
The plasticity of development: how knowledge of epigenetics may advance understanding of eating disorders.
机构信息
Department of Psychiatry & Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, David Geffen School of Medicine, University of California, Los Angeles; Stewart & Lynda Resnick Neuropsychiatric Hospital at UCLA, Los Angeles, California.
出版信息
Int J Eat Disord. 2014 Nov;47(7):696-704. doi: 10.1002/eat.22322. Epub 2014 Jun 27.
OBJECTIVE
To depict the processes through which animals and human beings engage their environment in continuously evolving states of conflict and cooperation.
METHOD
Descriptive literature review.
RESULTS
Life history outcomes are more relative than they are absolute. Genetic variations play a crucial role, but heavily influencing behavioral outcomes, psychopathology included, are external cues that epigenetically remodel DNA along experience-dependent signaling pathways. The result is phenotypes that either optimize adjustment, or constrain it.
DISCUSSION
Knowledge of epigenetic mechanisms may help shed new light on the origin of maturational phenotypes underlying eating disorders and why adjusting treatments to these realities warrants our attention.
目的
描绘动物和人类在不断变化的冲突与合作状态中与环境相互作用的过程。
方法
描述性文献综述。
结果
生命史的结果是相对的而不是绝对的。遗传变异起着至关重要的作用，但对行为结果，包括精神病理学，产生重大影响的是外部线索，它们通过经验依赖的信号通路对 DNA 进行表观遗传重塑。其结果是表现型，或者优化调整，或者限制调整。
讨论
对表观遗传机制的了解可能有助于阐明导致饮食失调的成熟表型的起源，以及为什么需要关注根据这些现实情况调整治疗方法。
Zotero 插件