Lockitch G, Pendray M R, Godolphin W J, Quigley G
Am J Clin Nutr. 1985 Jul;42(1):24-30. doi: 10.1093/ajcn/42.1.24.
One hundred and five infants of birth weight 2000 g or less who received peripherally administered parenteral nutrition for periods of three or more weeks, were randomly assigned to groups receiving different amounts of zinc and copper supplement. The blood concentrations of zinc, copper, retinol-binding protein, prealbumin, alkaline phosphatase and aspartate transaminase were followed weekly. Mean serum zinc, retinol-binding protein and prealbumin declined significantly over time while alkaline phosphatase rose. Only the group receiving the highest zinc supplement maintained a mean serum zinc concentration within the normal range at seven weeks. No difference in the protein or enzyme concentrations was found between the different zinc supplement groups. No difference was seen in serum copper or ceruloplasmin between copper dose groups although one intravenous supplement was double that of the other.
105名出生体重2000克及以下且接受外周肠外营养3周及以上的婴儿被随机分为接受不同剂量锌和铜补充剂的组。每周监测锌、铜、视黄醇结合蛋白、前白蛋白、碱性磷酸酶和天冬氨酸转氨酶的血浓度。随着时间的推移，平均血清锌、视黄醇结合蛋白和前白蛋白显著下降，而碱性磷酸酶上升。只有接受最高锌补充剂的组在7周时平均血清锌浓度维持在正常范围内。不同锌补充剂组之间的蛋白质或酶浓度没有差异。尽管一种静脉补充剂的剂量是另一种的两倍，但铜剂量组之间的血清铜或铜蓝蛋白没有差异。
