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伯氏疟原虫感染可改善NC/Nga小鼠的特应性皮炎样皮肤损伤。

Plasmodium berghei infection ameliorates atopic dermatitis-like skin lesions in NC/Nga mice.

作者信息

Kishi C, Amano H, Suzue K, Ishikawa O

机构信息

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.

出版信息

Allergy. 2014 Oct;69(10):1412-9. doi: 10.1111/all.12472. Epub 2014 Aug 18.

DOI:10.1111/all.12472
PMID:24976451
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4329412/
Abstract

BACKGROUND

Atopic diseases are more prevalent in industrialized countries than in developing countries. In addition, significant differences in the prevalence of allergic diseases are observed between rural and urban areas within the same country. This difference in prevalence has been attributed to what is called the 'hygiene hypothesis'. Although parasitic infections are known to protect against allergic reactions, the mechanism is still unknown. The aim of this study was to investigate whether or not malarial infections can inhibit atopic dermatitis (AD)-like skin lesions in a mouse model of AD.

METHODS

We used NC/Nga mice which are a model for AD. The NC/Nga mice were intraperitoneally infected with 1 × 10(5) Plasmoduim berghei (Pb) XAT-infected erythrocytes.

RESULTS

Malarial infections ameliorated AD-like skin lesions in the NC/Nga mice. This improvement was blocked by the administration of anti-asialo GM1 antibodies, which are anti-natural killer (NK) cells. Additionally, adoptive transfer of NK cells markedly improved AD-like skin lesions in conventional NC/Nga mice; these suggest that the novel protective mechanism associated with malaria parasitic infections is at least, in part, dependent on NK cells.

CONCLUSIONS

We have experimentally demonstrated for the first time that malarial infections ameliorated AD-like skin lesions in a mouse model of AD. Our study could explain in part the mechanism of the 'hygiene hypothesis', which states that parasitic infections can inhibit the development of allergic diseases.

摘要

背景

过敏性疾病在工业化国家比在发展中国家更为普遍。此外，在同一个国家内，农村和城市地区的过敏性疾病患病率也存在显著差异。这种患病率的差异被归因于所谓的“卫生假说”。虽然已知寄生虫感染可预防过敏反应，但其机制仍不清楚。本研究的目的是调查疟原虫感染是否能在特应性皮炎（AD）小鼠模型中抑制类AD皮肤损伤。

方法

我们使用NC/Nga小鼠作为AD模型。将1×10⁵ 感染伯氏疟原虫（Pb）XAT的红细胞腹腔注射到NC/Nga小鼠体内。

结果

疟原虫感染改善了NC/Nga小鼠的类AD皮肤损伤。这种改善被抗去唾液酸GM1抗体（抗自然杀伤（NK）细胞抗体）的给药所阻断。此外，NK细胞的过继转移显著改善了常规NC/Nga小鼠的类AD皮肤损伤；这些结果表明，与疟原虫感染相关的新的保护机制至少部分依赖于NK细胞。

结论

我们首次通过实验证明，疟原虫感染可改善AD小鼠模型中的类AD皮肤损伤。我们的研究可以部分解释“卫生假说”的机制，该假说认为寄生虫感染可抑制过敏性疾病的发展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3acc/4329412/b78ff3d0603c/all0069-1412-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3acc/4329412/b2543f32841e/all0069-1412-f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3acc/4329412/f279b49b5c50/all0069-1412-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3acc/4329412/61b632ce4d06/all0069-1412-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3acc/4329412/660e08a6307b/all0069-1412-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3acc/4329412/b78ff3d0603c/all0069-1412-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3acc/4329412/b2543f32841e/all0069-1412-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3acc/4329412/dcfefa36431c/all0069-1412-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3acc/4329412/f279b49b5c50/all0069-1412-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3acc/4329412/61b632ce4d06/all0069-1412-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3acc/4329412/660e08a6307b/all0069-1412-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3acc/4329412/b78ff3d0603c/all0069-1412-f6.jpg

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本文引用的文献

1
Natural killer cells in patients with allergic diseases.过敏性疾病患者体内的自然杀伤细胞。
J Allergy Clin Immunol. 2013 Sep;132(3):527-535. doi: 10.1016/j.jaci.2013.07.030.
2
Malaria.疟疾。
Lancet. 2014 Feb 22;383(9918):723-35. doi: 10.1016/S0140-6736(13)60024-0. Epub 2013 Aug 15.
3
Atopic dermatitis: a candidate for disease-modifying strategy.特应性皮炎：一种有潜力的疾病修正治疗策略。
Allergy. 2012 Aug;67(8):969-75. doi: 10.1111/j.1398-9995.2012.02845.x. Epub 2012 Jun 4.
4
Oral application of bacterial lysate in infancy decreases the risk of atopic dermatitis in children with 1 atopic parent in a randomized, placebo-controlled trial.一项随机、安慰剂对照试验表明，在有 1 位特应性父母的儿童中，口服细菌裂解物可降低特应性皮炎的发病风险。
J Allergy Clin Immunol. 2012 Apr;129(4):1040-7. doi: 10.1016/j.jaci.2012.02.005.
5
The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells.转录因子 E4BP4 调节 CD4+T 细胞中 IL-10 和 IL-13 的产生。
Nat Immunol. 2011 May;12(5):450-9. doi: 10.1038/ni.2020. Epub 2011 Apr 3.
6
Contrasting pathogenesis of atopic dermatitis and psoriasis--part I: clinical and pathologic concepts.特应性皮炎和银屑病发病机制的对比——第 1 部分：临床和病理概念。
J Allergy Clin Immunol. 2011 May;127(5):1110-8. doi: 10.1016/j.jaci.2011.01.053. Epub 2011 Mar 8.
7
Recent insights into atopic dermatitis and implications for management of infectious complications.特应性皮炎的新认识及其对感染性并发症管理的影响。
J Allergy Clin Immunol. 2010 Jan;125(1):4-13; quiz 14-5. doi: 10.1016/j.jaci.2009.11.027.
8
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New Microbiol. 2009 Jul;32(3):285-91.
9
The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development.碱性亮氨酸拉链转录因子E4BP4对自然杀伤细胞的发育至关重要。
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10
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