Yano M, Yokota H, Otsuka T
Department of Anesthesiology, Nippon Medical School, Japan.
No To Shinkei. 1989 Jan;41(1):27-33.
Fluid management, electrolyte balance and nutritional support had been examined for 14 days in 39 patients of severe head injury under intracranial pressure (ICP) monitoring. When ICP value exceeded 25 mmHg, barbiturate was administered in addition to the conventional therapy. Restriction of fluid administration should depend upon ICP values. When the ICP value was 20 mmHg or less and basal cisterns or ventricular systems were not obliterated in serial CT scan, fluid administration was not restricted in most patients. Mean urine volume was measured 2500 ml/day and mean water balance was measured about 0 to 700 ml/day with large deviation. Urine output and specific gravity was checked every hour and water balance was evaluated every day. When excess urine output or dehydration was recognized, additional fluid was given to keep within 500 ml/day in water balance. Through the examination, no patients of dehydration nor azotemia were experienced. Out of 39, 22 were survived and 17 were expired. In expired patients, 13 patients was recognized dead or brain death within 72 hours of injury. In two patients (one is suffered from severe brainstem injured patient with corpus callosal hemorrhage and another patient with post operative cerebral swelling) cerebral herniation was recognized about 72 hour after injury. Remaining 2 patients died after 7 days. Patients with hypernatremia were recognized 3 (13.7%) out of 22 survivals, and 14 (82.4%) out of 17 expired patients. It was recognized more common within 3 days of injury. Hypernatremia more than 160 mEq/l was accounted 5 (29.4%) in expired patients, but non in survivals.(ABSTRACT TRUNCATED AT 250 WORDS)
对39例接受颅内压(ICP)监测的重型颅脑损伤患者进行了为期14天的液体管理、电解质平衡及营养支持研究。当ICP值超过25 mmHg时,除常规治疗外还给予巴比妥类药物。液体输入的限制应取决于ICP值。当ICP值为20 mmHg或更低且连续CT扫描显示基底池或脑室系统未闭塞时,大多数患者不限制液体输入。平均尿量为2500 ml/天,平均水平衡约为0至700 ml/天,偏差较大。每小时检查尿量和比重,每天评估水平衡。当发现尿量过多或脱水时,额外补充液体以使水平衡保持在500 ml/天以内。通过检查,未出现脱水或氮质血症患者。39例患者中,22例存活,17例死亡。在死亡患者中,13例在受伤后72小时内被认定死亡或脑死亡。2例患者(1例为患有胼胝体出血的严重脑干损伤患者,另1例为术后脑肿胀患者)在受伤后约72小时出现脑疝。其余2例在7天后死亡。22例存活患者中有3例(13.7%)出现高钠血症,17例死亡患者中有14例(82.4%)出现高钠血症。在受伤后3天内更常见。高钠血症超过160 mEq/l的情况在死亡患者中占5例(29.4%),但存活患者中无此情况。(摘要截断于250字)