Su Xiu-Juan, Yuan Wei, Tan Hui, Liu Xiang-Yun, Li Dan, Li De-Kun, Huang Guo-Ying, Zhang Li-Wen, Miao Mao-Hua
Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, PR China.
Department of Reproductive Epidemiology and Social Science, National Population and Family Planning Key Laboratory of Contraceptive Drugs and Devices, Shanghai Institute of Planned Parenthood Research, Shanghai, PR China.
PLoS One. 2014 Jun 30;9(6):e101050. doi: 10.1371/journal.pone.0101050. eCollection 2014.
To explore the correlation between maternal magnetic field (MF) exposure in daily life and embryonic development.
A cross-sectional study was conducted among 149 pregnant women who were seeking induced abortion of unwanted pregnancies. Participating women were asked to wear an EMDEX Lite magnetic field meter for a 24-h period to obtain MF exposure level within 4 weeks following the abortion. Embryonic bud and sac lengths were measured through B-mode ultrasound before the surgical abortion. Embryo sections were prepared and examined for histological changes, and the apoptosis status of the deciduas was examined using the TUNEL apoptosis assay.
Embryonic bud length was inversely associated with maternal daily MF exposure level; the association was statistically significant at the time-weighted-average and 75th percentile of MF exposure levels, with coefficients of -3.09 (P = 0.0479) and -3.07 (P = 0.0228), respectively. Logistic regression for examining the risk of higher MF exposure indicated that women with her 75th percentile of daily MF measurements ≥0.82 mG had a 3.95-fold risk of having a fetus with a shorter embryonic bud length than those whose daily MF exposure were <0.82 mG. MF exposure was associated with a higher degree of apoptosis, but the association was not statistically significant. We failed to find a statistical correlation between MF exposure and embryonic sac length and histological changes in the first trimester.
Prenatal MF exposure may have an adverse effect on embryonic development.
探讨孕期日常生活中母体磁场（MF）暴露与胚胎发育之间的相关性。
对149例因意外怀孕而寻求人工流产的孕妇进行了一项横断面研究。要求参与研究的妇女佩戴EMDEX Lite磁场仪24小时，以获取流产后4周内的MF暴露水平。在人工流产前通过B超测量胎芽和孕囊长度。制备胚胎切片并检查组织学变化，使用TUNEL凋亡检测法检测蜕膜的凋亡状态。
胎芽长度与母体每日MF暴露水平呈负相关；在MF暴露水平的时间加权平均值和第75百分位数时，该相关性具有统计学意义，系数分别为-3.09（P = 0.0479）和-3.07（P = 0.0228）。用于检查较高MF暴露风险的逻辑回归分析表明，每日MF测量值第75百分位数≥0.82 mG的妇女，其胎儿胎芽长度较短的风险是每日MF暴露<0.82 mG的妇女的3.95倍。MF暴露与更高程度的凋亡相关，但该相关性无统计学意义。我们未发现MF暴露与孕早期孕囊长度及组织学变化之间存在统计学相关性。
孕期MF暴露可能对胚胎发育产生不利影响。
