Dove Jacob D, Borden Mark A, Murray Todd W
Opt Lett. 2014 Jul 1;39(13):3732-5. doi: 10.1364/OL.39.003732.
We report on the optical excitation and detection of resonant microbubble oscillations. Optically absorbing nanoparticles were attached to the shell of a lipid-encapsulated microbubble, allowing for optical pulsing to photothermally drive the microbubble into resonance. A modified optical microscope was used to track the bubble wall radius as a function of time using light scattering. The microbubble response from a nanosecond laser pulse was measured, and the eigenfrequency and vibrational amplitude were determined and compared to theory. The ability to optically drive microbubble oscillations may have applications in basic studies of bubble dynamics and biomedical imaging and therapy.
我们报告了共振微泡振荡的光学激发与检测。将光吸收纳米颗粒附着于脂质包裹微泡的外壳上，从而能够通过光脉冲以光热方式驱动微泡进入共振状态。使用经过改进的光学显微镜，利用光散射来跟踪气泡壁半径随时间的变化。测量了纳秒激光脉冲引起的微泡响应，并确定了本征频率和振动幅度，并与理论进行了比较。光学驱动微泡振荡的能力可能在气泡动力学的基础研究以及生物医学成像与治疗中具有应用价值。
