MacEwan Sarah R, Chilkoti Ashutosh
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA; Research Triangle MRSEC, Duke University, Durham, NC 27708, USA.
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA; Research Triangle MRSEC, Duke University, Durham, NC 27708, USA.
J Control Release. 2014 Sep 28;190:314-30. doi: 10.1016/j.jconrel.2014.06.028. Epub 2014 Jun 28.
Elastin-like polypeptides (ELPs) are biopolymers inspired by human elastin. Their lower critical solution temperature phase transition behavior and biocompatibility make them useful materials for stimulus-responsive applications in biological environments. Due to their genetically encoded design and recombinant synthesis, the sequence and size of ELPs can be exactly defined. These design parameters control the structure and function of the ELP with a precision that is unmatched by synthetic polymers. Due to these attributes, ELPs have been used extensively for drug delivery in a variety of different embodiments-as soluble macromolecular carriers, self-assembled nanoparticles, cross-linked microparticles, or thermally coacervated depots. These ELP systems have been used to deliver biologic therapeutics, radionuclides, and small molecule drugs to a variety of anatomical sites for the treatment of diseases including cancer, type 2 diabetes, osteoarthritis, and neuroinflammation.
类弹性蛋白多肽（ELPs）是受人类弹性蛋白启发的生物聚合物。它们的低临界溶液温度相变行为和生物相容性使其成为生物环境中刺激响应应用的有用材料。由于其基因编码设计和重组合成，ELPs的序列和大小可以精确界定。这些设计参数以合成聚合物无法比拟的精度控制ELP的结构和功能。由于这些特性，ELPs已在各种不同的实施方案中广泛用于药物递送——作为可溶性大分子载体、自组装纳米颗粒、交联微粒或热凝聚贮库。这些ELP系统已被用于将生物治疗剂、放射性核素和小分子药物递送至各种解剖部位，以治疗包括癌症、2型糖尿病、骨关节炎和神经炎症在内的疾病。
