Department of Biomedical Engineering, Duke University, Durham, NC, 277018, USA.
Adv Healthc Mater. 2021 Jul;10(13):e2100209. doi: 10.1002/adhm.202100209. Epub 2021 Jun 3.
Elastin-like polypeptides (ELPs) are thermally responsive biopolymers that consist of a repeated amino acid motif derived from human tropoelastin. These peptides exhibit temperature-dependent phase behavior that can be harnessed to produce stimuli-responsive biomaterials, such as nanoparticles or injectable drug delivery depots. As ELPs are genetically encoded, the properties of ELP-based biomaterials can be controlled with a precision that is unattainable with synthetic polymers. Unique ELP architectures, such as spherical or rod-like micelles or injectable coacervates, can be designed by manipulating the ELP amino acid sequence and length. ELPs can be loaded with drugs to create controlled, intelligent drug delivery systems. ELPs are biodegradable, nonimmunogenic, and tolerant of therapeutic additives. These qualities make ELPs exquisitely well-suited to address current challenges in drug delivery and have spurred the development of ELP-based therapeutics to treat diseases-such as cancer and diabetes-and to promote wound healing. This review focuses on the use of ELPs in drug delivery systems.
弹性蛋白样多肽 (ELPs) 是热响应性生物聚合物，由源自人原弹性蛋白的重复氨基酸基序组成。这些肽表现出温度依赖性的相行为，可用于生产对刺激有响应的生物材料，如纳米颗粒或可注射的药物递送库。由于 ELP 是基因编码的，因此基于 ELP 的生物材料的性质可以通过与合成聚合物无法实现的精度来控制。通过操纵 ELP 氨基酸序列和长度，可以设计具有独特 ELP 结构的球形或棒状胶束或可注射凝聚物。可以将药物加载到 ELP 中以创建控制的智能药物递送系统。ELP 可生物降解、无免疫原性且耐受治疗性添加剂。这些特性使 ELP 非常适合解决药物递送中的当前挑战，并促使开发基于 ELP 的疗法来治疗疾病，如癌症和糖尿病，并促进伤口愈合。本综述重点介绍了 ELP 在药物递送系统中的应用。
