Korbad Balaji L, Lee Sang-Hyeup
Department of Life Chemistry, Catholic University of Daegu, Gyeongsan-si, Gyeongbuk 712-702, South Korea.
Chem Commun (Camb). 2014 Aug 18;50(64):8985-8. doi: 10.1039/c4cc04111a.
Synthesis of N-aryl substituted, five- and six-membered azacycloalkanes, isoindolines and tetrahydroisoquinolines, has been described. In this synthesis, cyclic ethers (n = 1, 2) were treated with dimethylaluminum-amide reagents, derived from a range of aryl amines and trimethylaluminum, to afford the corresponding azacycles in good yields.
已报道了N-芳基取代的五元及六元氮杂环烷烃、异吲哚啉和四氢异喹啉的合成。在该合成中，环醚（n = 1, 2）与由一系列芳基胺和三甲基铝衍生而来的二甲基铝酰胺试剂反应，以良好的产率得到相应的氮杂环。
