人类免疫缺陷病毒感染抑制剂的合成
Synthesis of an inhibitor of human immunodeficiency virus infection.
作者信息
Hatanaka K, Yoshida T, Uryu T, Yoshida O, Nakashima H, Yamamoto N, Mimura T, Kaneko Y
机构信息
Institute of Industrial Science, University of Tokyo.
出版信息
Jpn J Cancer Res. 1989 Feb;80(2):95-8. doi: 10.1111/j.1349-7006.1989.tb02272.x.
Anti-HIV effects of lentinan sulfate were investigated by using an HTLV-I-carrying cell line, MT-4, in vitro. Lentinan, a fungal branched (1----3)-beta-D-glucan, was sulfated to various degrees by means of two kinds of procedures using piperidine N-sulfonic acid in dimethyl sulfoxide or chlorosulfonic acid in pyridine. Lentinan sulfate with a sulfur content of more than 13.9% effectively prevented HIV-induced cytopathic effects (CPE) at concentrations of more than 3.3 micrograms/ml. However, low-substituted lentinan sulfate did not prevent HIV-induced CPE at any concentration tested. When the countercation was 50% Na+ and 50% pyridinium ion, the inhibitory capacity was low. Anticoagulant activity of the lentinan sulfate was also assessed.
通过使用携带HTLV-I的细胞系MT-4在体外研究了硫酸化香菇多糖的抗HIV作用。香菇多糖是一种真菌来源的分支（1→3）-β-D-葡聚糖，通过在二甲基亚砜中使用哌啶N-磺酸或在吡啶中使用氯磺酸的两种方法将其硫酸化至不同程度。硫含量超过13.9%的硫酸化香菇多糖在浓度高于3.3微克/毫升时可有效预防HIV诱导的细胞病变效应（CPE）。然而，低取代度的硫酸化香菇多糖在任何测试浓度下均不能预防HIV诱导的CPE。当抗衡阳离子为50%Na+和50%吡啶离子时，抑制能力较低。还评估了硫酸化香菇多糖的抗凝活性。
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