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1
Inhibition of colony formation of drug-resistant human tumor cell lines by combinations of interleukin-2-activated killer cells and antitumor drugs.白细胞介素-2激活的杀伤细胞与抗肿瘤药物联合使用对耐药性人类肿瘤细胞系集落形成的抑制作用。
Jpn J Cancer Res. 1989 Mar;80(3):265-70. doi: 10.1111/j.1349-7006.1989.tb02303.x.
2
In vitro evaluation of the new anticancer agents KT6149, MX-2, SM5887, menogaril, and liblomycin using cisplatin- or adriamycin-resistant human cancer cell lines.使用顺铂或阿霉素耐药的人癌细胞系对新型抗癌药物KT6149、MX-2、SM5887、美诺立尔和利博霉素进行体外评估。
Cancer Res. 1989 Aug 1;49(15):4098-102.
3
Detection of NK activity and antibody-dependent cellular cytotoxicity of lymphocytes by human tumor clonogenic assay--its correlation with the 51Cr-release assay.用人肿瘤克隆形成试验检测淋巴细胞的自然杀伤活性及抗体依赖性细胞毒性——及其与51Cr释放试验的相关性。
Int J Cancer. 1985 Apr 15;35(4):449-55. doi: 10.1002/ijc.2910350406.
4
Sensitization of human bladder cancer cells to Fas-mediated cytotoxicity by cis-diamminedichloroplatinum (II).顺二氯二氨铂（II）使人类膀胱癌细胞对Fas介导的细胞毒性敏感化。
J Urol. 1998 Aug;160(2):561-70.
5
Cross-resistance to tumour promoters in human cancer cell lines resistant to adriamycin or cisplatin.对阿霉素或顺铂耐药的人癌细胞系中对肿瘤启动子的交叉耐药性。
Br J Cancer. 1990 Sep;62(3):415-9. doi: 10.1038/bjc.1990.309.
6
Antitumor activity of DA-125, a novel anthracycline, in human gastric and pulmonary adenocarcinoma cells resistant to adriamycin and cisplatin.新型蒽环类药物DA-125对耐阿霉素和顺铂的人胃及肺腺癌细胞的抗肿瘤活性。
Anticancer Res. 1997 Sep-Oct;17(5A):3613-6.
7
In vitro cytotoxicity of a novel antitumor antibiotic, spicamycin derivative, in human lung cancer cell lines.一种新型抗肿瘤抗生素——螺旋霉素衍生物在人肺癌细胞系中的体外细胞毒性
Cancer Res. 1995 Mar 1;55(5):1075-9.
8
Lymphokine-activated killer (LAK) and monocyte-mediated cytotoxicity on tumor cell lines resistant to antitumor agents.淋巴因子激活的杀伤细胞（LAK）和单核细胞对耐药肿瘤细胞系的细胞毒性作用。
Cell Immunol. 1989 Apr 15;120(1):250-8. doi: 10.1016/0008-8749(89)90192-5.
9
Therapeutic efficacy of interleukin-2 activated killer cells against adriamycin resistant mouse B16-BL6 melanoma.白细胞介素-2激活的杀伤细胞对阿霉素耐药小鼠B16-BL6黑色素瘤的治疗效果。
Anticancer Res. 1992 May-Jun;12(3):921-5.
10
[Low susceptibility of choriocarcinoma cell lines to lymphokine activated killer (LAK) cells].[绒毛膜癌细胞系对淋巴因子激活的杀伤细胞（LAK细胞）的低敏感性]
Nihon Sanka Fujinka Gakkai Zasshi. 1989 Jan;41(1):1-6.

引用本文的文献

1
P-glycoprotein-mediated multidrug resistance and lymphokine-activated killer cell susceptibility in ovarian carcinoma.卵巢癌中P-糖蛋白介导的多药耐药性与淋巴因子激活的杀伤细胞敏感性
J Clin Immunol. 1996 Nov;16(6):348-57. doi: 10.1007/BF01541671.
2
Drug resistance in rat colon cancer cell lines is associated with minor changes in susceptibility to cytotoxic cells.大鼠结肠癌细胞系中的耐药性与对细胞毒性细胞敏感性的微小变化有关。
Cancer Immunol Immunother. 1993 Oct;37(5):337-42. doi: 10.1007/BF01518457.

本文引用的文献

1
Tumor cell lipid composition and sensitivity to humoral immune killing. II. Influence of plasma membrane and intracellular lipid and fatty acid content.肿瘤细胞脂质组成与对体液免疫杀伤的敏感性。II. 质膜及细胞内脂质和脂肪酸含量的影响。
J Immunol. 1980 Aug;125(2):508-17.
2
Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.在用钙拮抗剂和钙调蛋白抑制剂孵育后，耐药P388肿瘤细胞中长春新碱和阿霉素的积累增加。
Cancer Res. 1982 Nov;42(11):4730-3.
3
Separation of leukocytes from blood and bone marrow. Introduction.从血液和骨髓中分离白细胞。引言。
Scand J Clin Lab Invest Suppl. 1968;97:7.
4
Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion.丁硫氨酸亚砜胺介导的谷胱甘肽耗竭增强阿霉素、美法仑和顺铂对耐药及敏感人卵巢癌细胞系的细胞毒性。
Biochem Pharmacol. 1985 Jul 15;34(14):2583-6. doi: 10.1016/0006-2952(85)90551-9.
5
Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer.对转移性癌症患者进行自体淋巴因子激活的杀伤细胞和重组白细胞介素-2全身给药的观察。
N Engl J Med. 1985 Dec 5;313(23):1485-92. doi: 10.1056/NEJM198512053132327.
6
Human tumor cell lines with pleiotropic drug resistance are efficiently killed by interleukin-2 activated killer cells and by activated monocytes.具有多药耐药性的人类肿瘤细胞系可被白细胞介素-2激活的杀伤细胞和活化的单核细胞有效杀伤。
Int J Cancer. 1987 Jul 15;40(1):104-7. doi: 10.1002/ijc.2910400119.
7
Detection of cytotoxicity of freshly obtained lymphocytes and of lymphocytes activated with recombinant interleukin II (rIL-2) against lung cancer cell lines by human tumor clonogenic assay (HTCA).
Eur J Cancer Clin Oncol. 1986 Apr;22(4):445-50. doi: 10.1016/0277-5379(86)90111-2.
8
Cyclosporin A reverses vincristine and daunorubicin resistance in acute lymphatic leukemia in vitro.环孢素A在体外可逆转急性淋巴细胞白血病对长春新碱和柔红霉素的耐药性。
J Clin Invest. 1986 Apr;77(4):1405-8. doi: 10.1172/JCI112450.
9
Establishment and characterization of cisplatin-resistant sublines of human lung cancer cell lines.
Int J Cancer. 1988 Mar 15;41(3):462-7. doi: 10.1002/ijc.2910410325.
10
In vitro growth inhibition of cisplatin-resistant human lung cancer cell lines by recombinant human tumor necrosis factor and/or recombinant human interferon-gamma by virtue of collateral sensitivity.重组人肿瘤坏死因子和/或重组人γ干扰素通过旁敏感性对顺铂耐药人肺癌细胞系的体外生长抑制作用
Jpn J Cancer Res. 1987 Nov;78(11):1274-80.

白细胞介素-2激活的杀伤细胞与抗肿瘤药物联合使用对耐药性人类肿瘤细胞系集落形成的抑制作用。

Inhibition of colony formation of drug-resistant human tumor cell lines by combinations of interleukin-2-activated killer cells and antitumor drugs.

作者信息

Ohtsu A, Sasaki Y, Tamura T, Fujiwara Y, Ohe Y, Minato K, Nakagawa K, Bungo M, Saijo N

机构信息

Department of Internal Medicine, National Cancer Center Hospital, Tokyo.

出版信息

Jpn J Cancer Res. 1989 Mar;80(3):265-70. doi: 10.1111/j.1349-7006.1989.tb02303.x.

DOI:10.1111/j.1349-7006.1989.tb02303.x
PMID:2498260
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5917724/
Abstract

The cytotoxicity of interleukin-2-activated killer (LAK) cells with or without anticancer drugs against cell lines with acquired drug resistance was evaluated in vitro by colony assay. Human non-small cell lung cancer cell lines, PC-9 and PC-14, human leukemia cell line, K-562, and their sublines resistant to cisplatin (CDDP), PC-9/CDDP and PC-14/CDDP, and to adriamycin (ADM), K-562/ADM, were used as target cells. PC-9/CDDP demonstrated a marked increase in susceptibility to killing by both peripheral blood lymphocytes (PBL) and LAK cells, as compared to the parental cell line, PC-9. The cytotoxicity of PBL and LAK cells against PC-14/CDDP and K-562/ADM was similar to that against their parental cell lines. Moreover, the combination of LAK and CDDP had a synergistic effect on PC-14 and PC-14/CDDP.

摘要

通过集落测定法在体外评估了白细胞介素-2激活的杀伤（LAK）细胞在有或没有抗癌药物的情况下对获得性耐药细胞系的细胞毒性。使用人非小细胞肺癌细胞系PC-9和PC-14、人白血病细胞系K-562及其对顺铂（CDDP）耐药的亚系PC-9/CDDP和PC-14/CDDP，以及对阿霉素（ADM）耐药的亚系K-562/ADM作为靶细胞。与亲代细胞系PC-9相比，PC-9/CDDP对外周血淋巴细胞（PBL）和LAK细胞杀伤的敏感性显著增加。PBL和LAK细胞对PC-14/CDDP和K-562/ADM的细胞毒性与其对亲代细胞系的细胞毒性相似。此外，LAK细胞与CDDP联合使用对PC-14和PC-14/CDDP具有协同作用。