A型肉毒杆菌毒素治疗中风后痉挛性马蹄内翻畸形。两种注射技术的比较。
Botulinum toxin type-A in the management of spastic equinovarus deformity after stroke. Comparison of 2 injection techniques.
作者信息
Otom Ali H, Al-Khawaja Imad M, Al-Quliti Khalid W
机构信息
Department of Rehabilitation Medicine, Royal Jordanian Rehabilitation Center, King Hussain Medical City, Amman, Jordan.
出版信息
Neurosciences (Riyadh). 2014 Jul;19(3):199-202.
OBJECTIVE
To retrospectively compare 2 injection techniques in the management of spastic equinovarus deformity after stroke.
METHODS
Patients with stroke were seen at King Hussein Medical Center, Amman, Jordan between January and December 2009. The study design involved an open label retrospective analysis of medical records of 2 groups of comparable age and onset of first stroke. Botulinum toxin was injected into the calf muscles at 2 sites in group I (12 patients) and 4 sites in group II (14 patients). Functional gain was evaluated by the time to walk 10 meters at month one, 3, and 6 compared with baseline.
RESULTS
There was significant improvement in walking time in each study group. However, there was no significant difference between the 2 groups as measured by the 10-meter walking time.
CONCLUSION
Fewer injection sites would minimize patient discomfort and possibly the production of antibodies, yielding similar therapeutic effects.
目的
回顾性比较两种注射技术在治疗中风后痉挛性马蹄内翻畸形中的应用。
方法
2009年1月至12月期间，在约旦安曼的侯赛因国王医疗中心对中风患者进行观察。该研究设计为对两组年龄和首次中风发病时间相当的患者的病历进行开放标签回顾性分析。第一组（12例患者）在小腿肌肉的2个部位注射肉毒杆菌毒素，第二组（14例患者）在4个部位注射。与基线相比，在第1、3和6个月时通过步行10米所需时间评估功能改善情况。
结果
每个研究组的步行时间均有显著改善。然而，通过10米步行时间测量，两组之间没有显著差异。
结论
较少的注射部位可将患者不适降至最低，并可能减少抗体产生，产生相似的治疗效果。
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